PDBe 6ei2

X-ray diffraction
1.61Å resolution

Crystal Structure of HLA-A68 presenting a C-terminally extended peptide

Released:
Source organism: Homo sapiens
Entry authors: Picaud S, Guillaume P, Pike ACW, von Delft F, Arrowsmith CH, Edwards AM, Bountra C, Gfeller D, Filippakopoulos P

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
HLA class I histocompatibility antigen, A-68 alpha chain Chain: A
Molecule details ›
Chain: A
Length: 276 amino acids
Theoretical weight: 31.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P01891 (Residues: 25-299; Coverage: 81%)
Gene names: HLA-A, HLAA
Sequence domains:
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
G1/S-specific cyclin-D2 Chain: C
Molecule details ›
Chain: C
Length: 10 amino acids
Theoretical weight: 1.09 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P30279 (Residues: 114-123; Coverage: 4%)
Gene name: CCND2

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P212121
Unit cell:
a: 59.061Å b: 80.247Å c: 110.88Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.159 0.158 0.181
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided