PDBe 6ehr

X-ray diffraction
2.9Å resolution

The crystal structure of the human LAMTOR-RagA CTD-RagC CTD complex

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero heptamer (preferred)
Entry contents:
7 distinct polypeptide molecules
Macromolecules (7 distinct):
Ragulator complex protein LAMTOR3 Chain: A
Molecule details ›
Chain: A
Length: 127 amino acids
Theoretical weight: 13.9 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9UHA4 (Residues: 1-124; Coverage: 100%)
Gene names: LAMTOR3, MAP2K1IP1, MAPKSP1, PRO2783
Sequence domains: Mitogen-activated protein kinase kinase 1 interacting
Ragulator complex protein LAMTOR2 Chain: B
Molecule details ›
Chain: B
Length: 126 amino acids
Theoretical weight: 13.57 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9Y2Q5 (Residues: 2-125; Coverage: 99%)
Gene names: HSPC003, LAMTOR2, MAPBPIP, ROBLD3
Sequence domains: Roadblock/LC7 domain
Ragulator complex protein LAMTOR5 Chain: C
Molecule details ›
Chain: C
Length: 91 amino acids
Theoretical weight: 9.62 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O43504 (Residues: 1-91; Coverage: 100%)
Gene names: HBXIP, LAMTOR5, XIP
Sequence domains: Ragulator complex protein LAMTOR5
Ragulator complex protein LAMTOR4 Chain: D
Molecule details ›
Chain: D
Length: 99 amino acids
Theoretical weight: 10.75 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q0VGL1 (Residues: 1-99; Coverage: 100%)
Gene names: C7orf59, LAMTOR4
Ragulator complex protein LAMTOR1 Chain: E
Molecule details ›
Chain: E
Length: 145 amino acids
Theoretical weight: 15.83 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q6IAA8 (Residues: 21-161; Coverage: 88%)
Gene names: C11orf59, LAMTOR1, PDRO, PP7157
Ras-related GTP-binding protein A Chain: F
Molecule details ›
Chain: F
Length: 132 amino acids
Theoretical weight: 15.29 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q7L523 (Residues: 183-313; Coverage: 42%)
Gene name: RRAGA
Ras-related GTP-binding protein C Chain: G
Molecule details ›
Chain: G
Length: 163 amino acids
Theoretical weight: 18.17 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9HB90 (Residues: 239-399; Coverage: 40%)
Gene name: RRAGC

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P212121
Unit cell:
a: 87.09Å b: 92.448Å c: 127.2Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.219 0.216 0.263
Expression system: Spodoptera frugiperda