PDBe 6edf

X-ray diffraction
1.4Å resolution

Fragment of a tyrosine-protein kinase

Released:
Source organism: Homo sapiens
Entry authors: Tempel W, Huang H, Sochirca I, Liu K, Bountra C, Arrowsmith CH, Edwards AM, Sidhu SS, Min J, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase Fyn Chain: A
Molecule details ›
Chain: A
Length: 79 amino acids
Theoretical weight: 8.59 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P06241 (Residues: 83-146; Coverage: 12%)
Gene name: FYN
Sequence domains: SH3 domain

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08ID-1
Spacegroup: P21
Unit cell:
a: 23.991Å b: 36.233Å c: 38.646Å
α: 90° β: 99.52° γ: 90°
R-values:
R R work R free
0.145 0.143 0.172
Expression system: Escherichia coli