PDBe 6cmp

X-ray diffraction
1.8Å resolution

Closed structure of inactive SHP2 mutant C459E

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein phosphatase non-receptor type 11 Chains: A, B
Molecule details ›
Chains: A, B
Length: 532 amino acids
Theoretical weight: 61.03 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q06124 (Residues: 1-533; Coverage: 89%)
  • Best match: Q06124-2 (Residues: 1-529)
Gene names: PTP2C, PTPN11, SHPTP2
Sequence domains:

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: P212121
Unit cell:
a: 54.75Å b: 84.91Å c: 211.92Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.202 0.201 0.231
Expression system: Escherichia coli BL21(DE3)