PDBe 6cfp

X-ray diffraction
2.45Å resolution

CRYSTAL STRUCTURE OF POLYMERASE ACID PROTEIN (PA) FROM INFLUENZA A VIRUS, WILSON-SMITH/1933 (H1N1) BOUND TO FRAGMENT HIT BSI-70565 1-{1-[4-FLUOROPHENYL)METHYL]-2-METHYL-1H-IMIDAZOL-4-YL}ETHAN-1-ONE

Released:
Entry author: Seattle Structural Genomics Center for Infectious Disease (SSGCID)

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Polymerase acidic protein; Ubiquitin-like protein SMT3 Chain: A
Molecule details ›
Chain: A
Length: 559 amino acids
Theoretical weight: 64.14 KDa
Source organisms: Expression system: Escherichia coli
UniProt:
  • Canonical: Q12306 (Residues: 13-98; Coverage: 85%)
  • Canonical: P15659 (Residues: 254-716; Coverage: 65%)
  • nullnull
Gene names: D9719.15, PA, SMT3, YDR510W
Sequence domains: Ubiquitin family

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P6522
Unit cell:
a: 68.82Å b: 68.82Å c: 397.82Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.179 0.179 0.231
Expression system: Escherichia coli