PDBe 6ce7

Electron Microscopy
7.4Å resolution

Insulin Receptor ectodomain in complex with one insulin molecule

Released:

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Insulin receptor subunit alpha Chains: A, B
Molecule details ›
Chains: A, B
Length: 929 amino acids
Theoretical weight: 105.93 KDa
Source organism: Homo sapiens
Expression system: Mus musculus
UniProt:
  • Canonical: P06213 (Residues: 28-956; Coverage: 69%)
Gene name: INSR
Sequence domains:
Insulin A chain Chain: N
Molecule details ›
Chain: N
Length: 21 amino acids
Theoretical weight: 2.38 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01308 (Residues: 90-110; Coverage: 24%)
Gene name: INS
Insulin B chain Chain: O
Molecule details ›
Chain: O
Length: 30 amino acids
Theoretical weight: 3.4 KDa
Source organism: Ovis aries
Expression system: Not provided
UniProt:
  • Canonical: P01318 (Residues: 25-54; Coverage: 37%)
Gene name: INS
Insulin receptor subunit alpha Chain: P
Molecule details ›
Chain: P
Length: 30 amino acids
Theoretical weight: 3.67 KDa
Source organism: Homo sapiens
Expression system: Mus musculus
UniProt:
  • Canonical: P06213 (Residues: 718-746; Coverage: 2%)
  • Best match: P06213-2 (Residues: 718-747)
Gene name: INSR

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 7.4Å
Relevant EMDB volumes: EMD-7461
Expression systems:
  • Mus musculus
  • Not provided