PDBe 6bze

Electron Microscopy
4Å resolution

Cryo-EM structure of BCL10 CARD filament

Source organism: Homo sapiens
Primary publication:
Assembly mechanism of the CARMA1-BCL10-MALT1-TRAF6 signalosome.
Proc. Natl. Acad. Sci. U.S.A. (2018)
PMID: 29382759
Related structures: EMD-7314

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo octamer (preferred)
Entry contents:
1 distinct polypeptide molecule
B-cell lymphoma/leukemia 10 Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 106 amino acids
Theoretical weight: 12.61 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: O95999 (Residues: 10-115; Coverage: 46%)
Gene names: BCL10, CIPER, CLAP
Sequence domains: Caspase recruitment domain

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Relevant EMDB volumes: EMD-7314
Expression system: Escherichia coli