PDBe 6bw5

X-ray diffraction
3.1Å resolution

Human GPT (DPAGT1) in complex with tunicamycin

Released:

Function and Biology Details

Reaction catalysed:
UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UMP + N-acetyl-D-glucosaminyl-diphosphodolichol
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 417 amino acids
Theoretical weight: 47.16 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9H3H5 (Residues: 1-408; Coverage: 100%)
Gene names: DPAGT1, DPAGT2
Sequence domains: Glycosyl transferase family 4

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: C2
Unit cell:
a: 212.272Å b: 105.512Å c: 149.389Å
α: 90° β: 103.53° γ: 90°
R-values:
R R work R free
0.258 0.256 0.288
Expression system: Spodoptera frugiperda