PDBe 6biy

X-ray diffraction
2.05Å resolution

HLA-DRB1 in complex with Histone 2B peptide

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
HLA class II histocompatibility antigen, DR alpha chain Chain: A
Molecule details ›
Chain: A
Length: 189 amino acids
Theoretical weight: 21.92 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01903 (Residues: 26-206; Coverage: 79%)
Gene names: HLA-DRA, HLA-DRA1
Sequence domains:
HLA class II histocompatibility antigen, DRB1-4 beta chain Chain: B
Molecule details ›
Chain: B
Length: 200 amino acids
Theoretical weight: 23.29 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P13760 (Residues: 30-219; Coverage: 80%)
Gene name: HLA-DRB1
Sequence domains:
Histone H2B type 1-A Chain: C
Molecule details ›
Chain: C
Length: 13 amino acids
Theoretical weight: 1.51 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q96A08 (Residues: 70-82; Coverage: 10%)
Gene names: HIST1H2BA, TSH2B

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: C2221
Unit cell:
a: 67.826Å b: 182.478Å c: 76.807Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.185 0.183 0.232
Expression systems:
  • Homo sapiens
  • Not provided