PDBe 6be6

X-ray diffraction
2.8Å resolution

ADAM10 Extracellular Domain


Function and Biology Details

Reaction catalysed:
Endopeptidase of broad specificity.
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Disintegrin and metalloproteinase domain-containing protein 10 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 449 amino acids
Theoretical weight: 49.56 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: O14672 (Residues: 214-654; Coverage: 61%)
Gene names: ADAM10, KUZ, MADM
Sequence domains:

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P21212
Unit cell:
a: 131.42Å b: 188.78Å c: 86.64Å
α: 90° β: 90° γ: 90°
R R work R free
0.239 0.236 0.284
Expression system: Spodoptera frugiperda