PDBe 6b1n

X-ray diffraction
1.8Å resolution

Disrupted hydrogen bond network impairs ATPase activity in an Hsc70 cysteine mutant

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Heat shock cognate 71 kDa protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 400 amino acids
Theoretical weight: 44.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P11142 (Residues: 5-381; Coverage: 58%)
Gene names: HSC70, HSP73, HSPA10, HSPA8

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: P21
Unit cell:
a: 73.388Å b: 77.598Å c: 75.523Å
α: 90° β: 101.16° γ: 90°
R-values:
R R work R free
0.185 0.184 0.226
Expression system: Escherichia coli