PDBe 6azp

X-ray diffraction
2.29Å resolution

A Structurally Dynamic N-terminal Region Drives Function of the Staphylococcal Peroxidase Inhibitor (SPIN)

Released:

Function and Biology Details

Reaction catalysed:
Cl(-) + H(2)O(2) + H(+) = HClO + H(2)O
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Myeloperoxidase Chain: A
Molecule details ›
Chain: A
Length: 577 amino acids
Theoretical weight: 65.84 KDa
Source organism: Homo sapiens
Expression system: Mus musculus
UniProt:
  • Canonical: P05164 (Residues: 167-743; Coverage: 83%)
Gene name: MPO
Sequence domains: Animal haem peroxidase
Staphylococcal Peroxidase Inhibitor Chain: B
Molecule details ›
Chain: B
Length: 60 amino acids
Theoretical weight: 6.92 KDa
Source organism: Staphylococcus aureus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q2G0X2 (Residues: 43-102; Coverage: 82%)
Gene name: SAOUHSC_00401

Ligands and Environments

3 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: C2
Unit cell:
a: 128.854Å b: 92.876Å c: 80.46Å
α: 90° β: 119.91° γ: 90°
R-values:
R R work R free
0.182 0.179 0.229
Expression systems:
  • Mus musculus
  • Escherichia coli BL21(DE3)