PDBe 6avr

Electron Microscopy
35Å resolution

Human alpha-V beta-3 Integrin (intermediate conformation) in complex with the therapeutic antibody LM609

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Integrin alpha-V Chain: A
Molecule details ›
Chain: A
Length: 957 amino acids
Theoretical weight: 105.89 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: NEW P06756 (Residues: 31-987; Coverage: 94%)
Gene names: ITGAV, MSK8, VNRA, VTNR
Sequence domains:
Integrin beta-3 Chain: B
Molecule details ›
Chain: B
Length: 692 amino acids
Theoretical weight: 76.52 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: NEW P05106 (Residues: 27-718; Coverage: 91%)
Gene names: GP3A, ITGB3
Sequence domains:
Fab LM609 heavy chain Chain: H
Molecule details ›
Chain: H
Length: 257 amino acids
Theoretical weight: 27.22 KDa
Source organism: Mus musculus
Expression system: Drosophila melanogaster
Fab LM609 light chain Chain: L
Molecule details ›
Chain: L
Length: 214 amino acids
Theoretical weight: 23.63 KDa
Source organism: Mus musculus
Expression system: Drosophila melanogaster

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 35Å
Relevant EMDB volumes: EMD-7012
Expression system: Drosophila melanogaster