PDBe 6avg

X-ray diffraction
2.6Å resolution

Crystal structure of the KFJ37 TCR-NY-ESO-1-HLA-B*07:02 complex

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
Beta-2-microglobulin Chains: A, H
Molecule details ›
Chains: A, H
Length: 107 amino acids
Theoretical weight: 12.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 13-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
T-cell receptor alpha variable 4,TCR alpha chain Chains: B, C
Molecule details ›
Chains: B, C
Length: 202 amino acids
Theoretical weight: 22.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
T-cell receptor beta variable 9,TCR beta chain Chains: D, E
Molecule details ›
Chains: D, E
Length: 245 amino acids
Theoretical weight: 27.55 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
HLA class I histocompatibility antigen, B-7 alpha chain Chains: F, G
Molecule details ›
Chains: F, G
Length: 362 amino acids
Theoretical weight: 40.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01889 (Residues: 1-362; Coverage: 100%)
Gene names: HLA-B, HLAB
Sequence domains:
Cancer/testis antigen 1 Chains: P, Q
Molecule details ›
Chains: P, Q
Length: 13 amino acids
Theoretical weight: 1.15 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P78358 (Residues: 60-72; Coverage: 7%)
Gene names: CTAG, CTAG1, CTAG1A, CTAG1B, ESO1, LAGE2, LAGE2A, LAGE2B

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P1
Unit cell:
a: 66.805Å b: 74.863Å c: 96.276Å
α: 94.22° β: 97.88° γ: 90.16°
R-values:
R R work R free
0.196 0.193 0.248
Expression systems:
  • Escherichia coli
  • Not provided