PDBe 6aru

X-ray diffraction
3.2Å resolution

Structure of Cetuximab Fab mutant in complex with EGFR extracellular domain

Released:
Source organism: Homo sapiens
Entry authors: Christie M, Christ D

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Epidermal growth factor receptor Chain: A
Molecule details ›
Chain: A
Length: 622 amino acids
Theoretical weight: 69.02 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt: Gene names: EGFR, ERBB, ERBB1, HER1
Sequence domains:
Cetuximab mutant light chain,Uncharacterized protein Chain: B
Molecule details ›
Chain: B
Length: 214 amino acids
Theoretical weight: 23.5 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Cetuximab mutant heavy chain Fab fragment,Immunoglobulin gamma-1 heavy chain Chain: C
Molecule details ›
Chain: C
Length: 222 amino acids
Theoretical weight: 23.83 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P21
Unit cell:
a: 77.495Å b: 70.444Å c: 149.079Å
α: 90° β: 100.95° γ: 90°
R-values:
R R work R free
0.234 0.232 0.267
Expression system: Homo sapiens