PDBe 6ao5

X-ray diffraction
2.96Å resolution

Crystal structure of human MST2 in complex with SAV1 SARAH domain

Released:

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Serine/threonine-protein kinase 3 Chain: A
Molecule details ›
Chain: A
Length: 362 amino acids
Theoretical weight: 41.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q13188 (Residues: 16-491; Coverage: 74%)
Gene names: KRS1, MST2, STK3
Sequence domains:
Protein salvador homolog 1 Chain: B
Molecule details ›
Chain: B
Length: 93 amino acids
Theoretical weight: 11.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9H4B6 (Residues: 291-383; Coverage: 24%)
Gene names: SAV1, WW45

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: R32
Unit cell:
a: 223.678Å b: 223.678Å c: 79.645Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.236 0.235 0.256
Expression system: Escherichia coli BL21(DE3)