PDBe 6amw

Solution NMR

Abl1b Regulatory Module 'Activating' conformation

Released:
Source organism: Homo sapiens
Primary publication:
Atomic view of the energy landscape in the allosteric regulation of Abl kinase.
Nat. Struct. Mol. Biol. (2017)
PMID: 28945248

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase ABL1 Chain: A
Molecule details ›
Chain: A
Length: 255 amino acids
Theoretical weight: 28.35 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P00519 (Residues: 6-12, 13-236; Coverage: 20%)
  • Best match: P00519-2 (Residues: 1-255)
Gene names: ABL, ABL1, JTK7
Sequence domains:

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 87%
Refinement method: molecular dynamics
Chemical shifts: BMR30332  
Expression system: Escherichia coli BL21