EC 3.1.3.48: Protein-tyrosine-phosphatase
Reaction catalysed:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Systematic name:
Protein-tyrosine-phosphate phosphohydrolase
Alternative Name(s):
- (Phosphotyrosine)protein phosphatase
- PPT-phosphatase
- PTP-phosphatase
- PTPase
- Phosphoprotein phosphatase (phosphotyrosine)
- Phosphotyrosine histone phosphatase
- Phosphotyrosine phosphatase
- Phosphotyrosine protein phosphatase
- Phosphotyrosylprotein phosphatase
- Protein phosphotyrosine phosphatase
- Tyrosine O-phosphate phosphatase
- Tyrosylprotein phosphatase
GO terms
Biochemical function:
- protein tyrosine kinase binding
- molecular adaptor activity
- peptide hormone receptor binding
- cell adhesion molecule binding
- cadherin binding
- receptor tyrosine kinase binding
- signaling receptor complex adaptor activity
- protein kinase binding
- hydrolase activity
- protein binding
- insulin receptor binding
- non-membrane spanning protein tyrosine phosphatase activity
- protein tyrosine phosphatase activity
- phosphoprotein phosphatase activity
- phosphotyrosine residue binding
Biological process:
- cellular response to epidermal growth factor stimulus
- cellular response to organic substance
- positive regulation of ERK1 and ERK2 cascade
- intestinal epithelial cell migration
- regulation of type I interferon-mediated signaling pathway
- face morphogenesis
- negative regulation of growth hormone secretion
- Bergmann glial cell differentiation
- negative regulation of cortisol secretion
- positive regulation of peptidyl-tyrosine phosphorylation
- homeostasis of number of cells within a tissue
- inner ear development
- genitalia development
- multicellular organismal reproductive process
- ephrin receptor signaling pathway
- neurotrophin TRK receptor signaling pathway
- platelet-derived growth factor receptor signaling pathway
- negative regulation of hormone secretion
- positive regulation of hormone secretion
- regulation of protein export from nucleus
- negative regulation of insulin secretion
- positive regulation of insulin receptor signaling pathway
- positive regulation of glucose import
- positive regulation of mitotic cell cycle
- positive regulation of ossification
- regulation of MAPK cascade
- regulation of protein-containing complex assembly
- glucose homeostasis
- hormone metabolic process
- ERBB signaling pathway
- atrioventricular canal development
- megakaryocyte development
- peptidyl-tyrosine dephosphorylation
- organ growth
- multicellular organism growth
- negative regulation of cell adhesion mediated by integrin
- regulation of cell adhesion mediated by integrin
- positive regulation of tumor necrosis factor production
- positive regulation of interleukin-6 production
- positive regulation of interferon-beta production
- microvillus organization
- negative regulation of type I interferon production
- negative regulation of chondrocyte differentiation
- T cell costimulation
- platelet formation
- cerebellar cortex formation
- cytokine-mediated signaling pathway
- dephosphorylation
- positive regulation of signal transduction
- hormone-mediated signaling pathway
- fibroblast growth factor receptor signaling pathway
- heart development
- brain development
- axonogenesis
- integrin-mediated signaling pathway
- epidermal growth factor receptor signaling pathway
- signal transduction
- triglyceride metabolic process
- lipid metabolic process
- protein dephosphorylation
- DNA damage checkpoint signaling
Cellular component:
Sequence families
Protein families (Pfam)
InterPro annotations
Structure domains
CATH domains
3.30.505.10
Class:
Alpha Beta
Architecture:
2-Layer Sandwich
Topology:
SHC Adaptor Protein
Homology:
SH2 domain
Occurring in:
