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Structure of human PARP1 catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor

Source organism: Homo sapiens
Biochemical function: NAD+ ADP-ribosyltransferase activity
Biological process: not assigned
Cellular component: not assigned

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EC 2.4.2.30: NAD(+) ADP-ribosyltransferase

Reaction catalysed:
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor
Systematic name:
NAD(+):poly(ADP-D-ribosyl)-acceptor ADP-D-ribosyl-transferase
Alternative Name(s):
  • ADP-ribosyltransferase (polymerizing)
  • NAD(+):poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase
  • NAD(+):poly(adenosine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase
  • Poly(ADP-ribose) synthase
  • Poly(ADP-ribose) synthetase
  • Poly(ADP-ribose)polymerase
  • Poly(adenosine diphosphate ribose) polymerase

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF00644
Domain description: Poly(ADP-ribose) polymerase catalytic domain
Occurring in:
  1. Poly [ADP-ribose] polymerase 1, processed C-terminus
The deposited structure of PDB entry 5wry contains 2 copies of Pfam domain PF00644 (Poly(ADP-ribose) polymerase catalytic domain) in Poly [ADP-ribose] polymerase 1, processed C-terminus. Showing 1 copy in chain B.

PF02877
Domain description: Poly(ADP-ribose) polymerase, regulatory domain
Occurring in:
  1. Poly [ADP-ribose] polymerase 1, processed C-terminus
The deposited structure of PDB entry 5wry contains 2 copies of Pfam domain PF02877 (Poly(ADP-ribose) polymerase, regulatory domain) in Poly [ADP-ribose] polymerase 1, processed C-terminus. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR012317
Domain description: Poly(ADP-ribose) polymerase, catalytic domain
Occurring in:
  1. Poly [ADP-ribose] polymerase 1, processed C-terminus
IPR004102
Domain description: Poly(ADP-ribose) polymerase, regulatory domain
Occurring in:
  1. Poly [ADP-ribose] polymerase 1, processed C-terminus
IPR036616
Domain description: Poly(ADP-ribose) polymerase, regulatory domain superfamily
Occurring in:
  1. Poly [ADP-ribose] polymerase 1, processed C-terminus

Structure domain

CATH CATH domain
3.90.228.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Phosphoenolpyruvate Carboxykinase; domain 3
Homology: Phosphoenolpyruvate Carboxykinase; domain 3
Occurring in:
  1. Poly [ADP-ribose] polymerase 1, processed C-terminus
The deposited structure of PDB entry 5wry contains 2 copies of CATH domain 3.90.228.10 (Phosphoenolpyruvate Carboxykinase; domain 3) in Poly [ADP-ribose] polymerase 1, processed C-terminus. Showing 1 copy in chain B.

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