› › Function and Biology

Crystal structure of Sec23a/Sec24a/Sec22 complexed with a C-terminal FA sorting motif

Source organisms:
Biochemical function: zinc ion binding
Biological process: endoplasmic reticulum to Golgi vesicle-mediated transport
Cellular component: COPII vesicle coat

Quick links

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF00626
Domain description: Gelsolin repeat
Occurring in:
  1. Protein transport protein Sec23A
  2. Protein transport protein Sec24A
The deposited structure of PDB entry 5vni contains 1 copy of Pfam domain PF00626 (Gelsolin repeat) in Protein transport protein Sec23A. Showing 1 copy in chain A.
The deposited structure of PDB entry 5vni contains 1 copy of Pfam domain PF00626 (Gelsolin repeat) in Protein transport protein Sec24A. Showing 1 copy in chain B.

PF04815
Domain description: Sec23/Sec24 helical domain
Occurring in:
  1. Protein transport protein Sec23A
  2. Protein transport protein Sec24A
The deposited structure of PDB entry 5vni contains 1 copy of Pfam domain PF04815 (Sec23/Sec24 helical domain) in Protein transport protein Sec23A. Showing 1 copy in chain A.
The deposited structure of PDB entry 5vni contains 1 copy of Pfam domain PF04815 (Sec23/Sec24 helical domain) in Protein transport protein Sec24A. Showing 1 copy in chain B.

PF08033
Domain description: Sec23/Sec24 beta-sandwich domain
Occurring in:
  1. Protein transport protein Sec23A
  2. Protein transport protein Sec24A
The deposited structure of PDB entry 5vni contains 1 copy of Pfam domain PF08033 (Sec23/Sec24 beta-sandwich domain) in Protein transport protein Sec23A. Showing 1 copy in chain A.
The deposited structure of PDB entry 5vni contains 1 copy of Pfam domain PF08033 (Sec23/Sec24 beta-sandwich domain) in Protein transport protein Sec24A. Showing 1 copy in chain B.

PF04811
Domain description: Sec23/Sec24 trunk domain
Occurring in:
  1. Protein transport protein Sec23A
  2. Protein transport protein Sec24A
The deposited structure of PDB entry 5vni contains 1 copy of Pfam domain PF04811 (Sec23/Sec24 trunk domain) in Protein transport protein Sec23A. Showing 1 copy in chain A.
The deposited structure of PDB entry 5vni contains 1 copy of Pfam domain PF04811 (Sec23/Sec24 trunk domain) in Protein transport protein Sec24A. Showing 1 copy in chain B.

PF04810
Domain description: Sec23/Sec24 zinc finger
Occurring in:
  1. Protein transport protein Sec23A
  2. Protein transport protein Sec24A
The deposited structure of PDB entry 5vni contains 1 copy of Pfam domain PF04810 (Sec23/Sec24 zinc finger) in Protein transport protein Sec23A. Showing 1 copy in chain A.
The deposited structure of PDB entry 5vni contains 1 copy of Pfam domain PF04810 (Sec23/Sec24 zinc finger) in Protein transport protein Sec24A. Showing 1 copy in chain B.

PF00957
Domain description: Synaptobrevin
Occurring in:
  1. Vesicle-trafficking protein SEC22b
The deposited structure of PDB entry 5vni contains 1 copy of Pfam domain PF00957 (Synaptobrevin) in Vesicle-trafficking protein SEC22b. Showing 1 copy in chain C.

PF13774
Domain description: Regulated-SNARE-like domain
Occurring in:
  1. Vesicle-trafficking protein SEC22b
The deposited structure of PDB entry 5vni contains 1 copy of Pfam domain PF13774 (Regulated-SNARE-like domain) in Vesicle-trafficking protein SEC22b. Showing 1 copy in chain C.

InterPro InterPro annotations
IPR010908
Domain description: Longin domain
Occurring in:
  1. Vesicle-trafficking protein SEC22b
IPR036465
Domain description: von Willebrand factor A-like domain superfamily
Occurring in:
  1. Protein transport protein Sec23A
  2. Protein transport protein Sec24A
IPR007123
Domain description: Gelsolin-like domain
Occurring in:
  1. Protein transport protein Sec23A
  2. Protein transport protein Sec24A
IPR029006
Domain description: ADF-H/Gelsolin-like domain superfamily
Occurring in:
  1. Protein transport protein Sec23A
  2. Protein transport protein Sec24A
IPR036180
Domain description: Gelsolin-like domain superfamily
Occurring in:
  1. Protein transport protein Sec23A
  2. Protein transport protein Sec24A
IPR036175
Domain description: Sec23/Sec24 helical domain superfamily
Occurring in:
  1. Protein transport protein Sec23A
  2. Protein transport protein Sec24A
IPR006900
Domain description: Sec23/Sec24, helical domain
Occurring in:
  1. Protein transport protein Sec23A
  2. Protein transport protein Sec24A
IPR012990
Domain description: Sec23/Sec24 beta-sandwich
Occurring in:
  1. Protein transport protein Sec23A
  2. Protein transport protein Sec24A
IPR006896
Domain description: Sec23/Sec24, trunk domain
Occurring in:
  1. Protein transport protein Sec23A
  2. Protein transport protein Sec24A
IPR006895
Domain description: Zinc finger, Sec23/Sec24-type
Occurring in:
  1. Protein transport protein Sec23A
  2. Protein transport protein Sec24A
IPR036174
Domain description: Zinc finger, Sec23/Sec24-type superfamily
Occurring in:
  1. Protein transport protein Sec23A
  2. Protein transport protein Sec24A
IPR044565
Domain description: Vesicle-trafficking protein Sec22
Occurring in:
  1. Vesicle-trafficking protein SEC22b
IPR011012
Domain description: Longin-like domain superfamily
Occurring in:
  1. Vesicle-trafficking protein SEC22b
IPR041742
Domain description: Sec24-like, trunk domain
Occurring in:
  1. Protein transport protein Sec24A
IPR037550
Domain description: Sec23, C-terminal
Occurring in:
  1. Protein transport protein Sec23A
IPR037364
Domain description: Protein transport protein Sec23
Occurring in:
  1. Protein transport protein Sec23A

Structure domains

CATH CATH domains
2.60.40.1670
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: beta-sandwich domain of Sec23/24
Occurring in:
  1. Protein transport protein Sec23A
  2. Protein transport protein Sec24A
The deposited structure of PDB entry 5vni contains 1 copy of CATH domain 2.60.40.1670 (Immunoglobulin-like) in Protein transport protein Sec23A. Showing 1 copy in chain A.
The deposited structure of PDB entry 5vni contains 1 copy of CATH domain 2.60.40.1670 (Immunoglobulin-like) in Protein transport protein Sec24A. Showing 1 copy in chain B.
1.20.120.730
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Four Helix Bundle (Hemerythrin (Met), subunit A)
Homology: Sec23/Sec24 helical domain
Occurring in:
  1. Protein transport protein Sec23A
  2. Protein transport protein Sec24A
The deposited structure of PDB entry 5vni contains 1 copy of CATH domain 1.20.120.730 (Four Helix Bundle (Hemerythrin (Met), subunit A)) in Protein transport protein Sec23A. Showing 1 copy in chain A.
The deposited structure of PDB entry 5vni contains 1 copy of CATH domain 1.20.120.730 (Four Helix Bundle (Hemerythrin (Met), subunit A)) in Protein transport protein Sec24A. Showing 1 copy in chain B.
2.30.30.380
Class: Mainly Beta
Architecture: Roll
Topology: SH3 type barrels.
Homology: Zn-finger domain of Sec23/24
Occurring in:
  1. Protein transport protein Sec23A
  2. Protein transport protein Sec24A
The deposited structure of PDB entry 5vni contains 1 copy of CATH domain 2.30.30.380 (SH3 type barrels.) in Protein transport protein Sec23A. Showing 1 copy in chain A.
The deposited structure of PDB entry 5vni contains 1 copy of CATH domain 2.30.30.380 (SH3 type barrels.) in Protein transport protein Sec24A. Showing 1 copy in chain B.
3.40.20.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Severin
Homology: Severin
Occurring in:
  1. Protein transport protein Sec23A
  2. Protein transport protein Sec24A
The deposited structure of PDB entry 5vni contains 1 copy of CATH domain 3.40.20.10 (Severin) in Protein transport protein Sec23A. Showing 1 copy in chain A.
The deposited structure of PDB entry 5vni contains 1 copy of CATH domain 3.40.20.10 (Severin) in Protein transport protein Sec24A. Showing 1 copy in chain B.
3.40.50.410
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: von Willebrand factor, type A domain
Occurring in:
  1. Protein transport protein Sec23A
  2. Protein transport protein Sec24A
The deposited structure of PDB entry 5vni contains 1 copy of CATH domain 3.40.50.410 (Rossmann fold) in Protein transport protein Sec23A. Showing 1 copy in chain A.
The deposited structure of PDB entry 5vni contains 1 copy of CATH domain 3.40.50.410 (Rossmann fold) in Protein transport protein Sec24A. Showing 1 copy in chain B.
3.30.450.50
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Beta-Lactamase
Homology: Longin domain
Occurring in:
  1. Vesicle-trafficking protein SEC22b
The deposited structure of PDB entry 5vni contains 1 copy of CATH domain 3.30.450.50 (Beta-Lactamase) in Vesicle-trafficking protein SEC22b. Showing 1 copy in chain C.

Quick links