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Crystal Structure of ATXR5 SET domain in complex with K36me3 histone H3 peptide

X-ray diffraction
1.949Å resolution
PDB entry 5vac coloured by chain, front view.
PDB entry 5vac coloured by chain, side view.
PDB entry 5vac coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Probable Histone-lysine N-methyltransferase ATXR5 and Histone H3.2
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Multimeric state: hetero dimer
Accessible surface area: 10147.95 Å2
Buried surface area: 2201.79 Å2
Dissociation area: 988.61 Å2
Dissociation energy (ΔGdiss): 9.45 kcal/mol
Dissociation entropy (TΔSdiss): 7.66 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-110885

Macromolecules

Probable Histone-lysine N-methyltransferase ATXR5
Chain: A
Length: 229 amino acids
Theoretical weight: 26.2 KDa
Source organism: Ricinus communis
Expression system: Escherichia coli
UniProt:
  • Canonical: B9RU15 (Residues: 146-374; Coverage: 61%)
Gene names: ATXR5, RCOM_1460410
Pfam: SET domain
InterPro:
CATH: SET domain
Probable Histone-lysine N-methyltransferase ATXR5 in PDB entry 5vac, assembly 1, front view.
Probable Histone-lysine N-methyltransferase ATXR5 in PDB entry 5vac, assembly 1, side view.
Probable Histone-lysine N-methyltransferase ATXR5 in PDB entry 5vac, assembly 1, top view.
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Histone H3.2
Chain: C
Length: 19 amino acids
Theoretical weight: 1.89 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q71DI3 (Residues: 19-37; Coverage: 14%)
Gene names: H3C13, H3C14, H3C15, H3F2, H3FM, HIST2H3A, HIST2H3C, HIST2H3D
Histone H3.2 in PDB entry 5vac, assembly 1, front view.
Histone H3.2 in PDB entry 5vac, assembly 1, side view.
Histone H3.2 in PDB entry 5vac, assembly 1, top view.
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