› › Structure analysis

USP7 in complex with GNE6776 (6'-amino-4'-ethyl-5'-(4-hydroxyphenyl)-N-methyl-[3,3'-bipyridine]-6-carboxamide)

X-ray diffraction
2.23Å resolution
PDB entry 5uqx coloured by chain, front view.
PDB entry 5uqx coloured by chain, side view.
PDB entry 5uqx coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Ubiquitin carboxyl-terminal hydrolase 7
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Multimeric state: monomeric
Accessible surface area: 17327.3 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-187973
Assembly 2
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Assembly Name: Ubiquitin carboxyl-terminal hydrolase 7
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Multimeric state: monomeric
Accessible surface area: 16462.17 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-187973

Macromolecules

Ubiquitin carboxyl-terminal hydrolase 7
Chains: A, B
Length: 369 amino acids
Theoretical weight: 42.63 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q93009 (Residues: 208-555; Coverage: 32%)
Gene names: HAUSP, USP7
Pfam: Ubiquitin carboxyl-terminal hydrolase
InterPro:
CATH: ubp-family deubiquitinating enzyme superfamily
Ubiquitin carboxyl-terminal hydrolase 7 in PDB entry 5uqx, assembly 1, front view.
Ubiquitin carboxyl-terminal hydrolase 7 in PDB entry 5uqx, assembly 1, side view.
Ubiquitin carboxyl-terminal hydrolase 7 in PDB entry 5uqx, assembly 1, top view.
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