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wild-type NRas bound to GppNHp

X-ray diffraction
1.672Å resolution
PDB entry 5uhv coloured by chain, front view.
PDB entry 5uhv coloured by chain, side view.
PDB entry 5uhv coloured by chain, top view.
Source organism: Homo sapiens
Assemblies composition:
monomeric (preferred)
homo dimer
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: GTPase NRas
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Multimeric state: monomeric
Accessible surface area: 7675.98 Å2
Buried surface area: 1153.83 Å2
Dissociation area: 88.53 Å2
Dissociation energy (ΔGdiss): 0.09 kcal/mol
Dissociation entropy (TΔSdiss): 0.8 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-133953
Assembly 2
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Assembly Name: GTPase NRas
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Multimeric state: homo dimer
Accessible surface area: 14006.27 Å2
Buried surface area: 3657.51 Å2
Dissociation area: 675.17 Å2
Dissociation energy (ΔGdiss): -5.07 kcal/mol
Dissociation entropy (TΔSdiss): 12.06 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-133955

Macromolecules

GTPase NRas
Chain: A
Length: 166 amino acids
Theoretical weight: 18.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01111 (Residues: 1-166; Coverage: 88%)
Gene names: HRAS1, NRAS
Pfam: Ras family
InterPro:
CATH: P-loop containing nucleotide triphosphate hydrolases
GTPase NRas in PDB entry 5uhv, assembly 1, front view.
GTPase NRas in PDB entry 5uhv, assembly 1, side view.
GTPase NRas in PDB entry 5uhv, assembly 1, top view.
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