PDBe 5twv

Electron Microscopy
6.3Å resolution

Cryo-EM structure of the pancreatic ATP-sensitive K+ channel SUR1/Kir6.2 in the presence of ATP and glibenclamide


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
ATP-binding cassette sub-family C member 8 Chains: B, D, F, H
Molecule details ›
Chains: B, D, F, H
Length: 1590 amino acids
Theoretical weight: 178.33 KDa
Source organism: Cricetus cricetus
Expression system: Rattus norvegicus
  • Canonical: Q09427 (Residues: 1-1582; Coverage: 100%)
Gene names: ABCC8, SUR
Sequence domains:
ATP-sensitive inward rectifier potassium channel 11 Chains: A, C, E, G
Molecule details ›
Chains: A, C, E, G
Length: 390 amino acids
Theoretical weight: 43.65 KDa
Source organism: Rattus norvegicus
Expression system: Rattus norvegicus
  • Canonical: P70673 (Residues: 1-390; Coverage: 100%)
Gene name: Kcnj11
Sequence domains: Inward rectifier potassium channel

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 6.3Å
Relevant EMDB volumes: EMD-8470
Expression system: Rattus norvegicus