› 5tqq

Electron Microscopy
3.76Å resolution

Cryo-electron microscopy structure of a bovine CLC-K chloride channel, main (class 1) conformation

Released:
DOI: 10.2210/pdb5tqq/pdb
PDB entry 5tqq coloured by chain, front view.
PDB entry 5tqq coloured by chain, side view.
PDB entry 5tqq coloured by chain, top view.
Source organisms:
Primary publication:
Structure of a CLC chloride ion channel by cryo-electron microscopy.
Park E, Campbell EB, MacKinnon R
Nature 541 500-505 (2017)
PMID: 28002411
Related structures: EMD-8435

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-207826 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Chloride channel protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 671 amino acids
Theoretical weight: 73.52 KDa
Source organism: Bos taurus
Expression system: Homo sapiens
UniProt:
  • Canonical: E1B792 (Residues: 27-687; Coverage: 96%)
Gene name: CLCNKA
Sequence domains: Voltage gated chloride channel
Structure domains: CBS-domain
Monoclonal antibody, Fab fragment, light chain Chains: L, M
Molecule details ›
Chains: L, M
Length: 107 amino acids
Theoretical weight: 11.82 KDa
Source organism: Mus musculus
Expression system: Mus musculus
Structure domains: Immunoglobulins
Monoclonal antibody, Fab fragment, heavy chain Chains: H, I
Molecule details ›
Chains: H, I
Length: 113 amino acids
Theoretical weight: 12.63 KDa
Source organism: Mus musculus
Expression system: Mus musculus

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.76Å
Relevant EMDB volumes: EMD-8435
Expression systems:
  • Homo sapiens
  • Mus musculus

Quick links

Citations

13 review citations

The form and function of channelrhodopsin.
Deisseroth et al. (2017)
12 more

18 mentions without citation

Chloride Channels in Astrocytes: Structure, Roles in Brain Homeostasis and Implications in Disease.
Elorza-Vidal et al. (2019)
17 more