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TEV Cleaved Human ATP Citrate Lyase Bound to Tartrate and ADP

X-ray diffraction
2Å resolution
PDB entry 5tdz coloured by chain, front view.
PDB entry 5tdz coloured by chain, side view.
PDB entry 5tdz coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: ATP-citrate synthase
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Multimeric state: hetero dimer
Accessible surface area: 28582.93 Å2
Buried surface area: 7684.31 Å2
Dissociation area: 2,384.47 Å2
Dissociation energy (ΔGdiss): 21.25 kcal/mol
Dissociation entropy (TΔSdiss): 14.23 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-156798

Macromolecules

ATP-citrate synthase
Chain: A
Length: 431 amino acids
Theoretical weight: 47.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P53396 (Residues: 1-425; Coverage: 39%)
Gene name: ACLY
Pfam: ATP citrate lyase citrate-binding
InterPro:
CATH:
ATP-citrate synthase in PDB entry 5tdz, assembly 1, front view.
ATP-citrate synthase in PDB entry 5tdz, assembly 1, side view.
ATP-citrate synthase in PDB entry 5tdz, assembly 1, top view.
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ATP-citrate synthase
Chain: B
Length: 324 amino acids
Theoretical weight: 35.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P53396 (Residues: 487-810; Coverage: 29%)
Gene name: ACLY
Pfam:
InterPro:
CATH:
ATP-citrate synthase in PDB entry 5tdz, assembly 1, front view.
ATP-citrate synthase in PDB entry 5tdz, assembly 1, side view.
ATP-citrate synthase in PDB entry 5tdz, assembly 1, top view.
Molecule details ›

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