› › Function and Biology

TEV Cleaved Human ATP Citrate Lyase Bound to 4S hydroxycitrate

Source organism: Homo sapiens
Biochemical function: acyltransferase activity, acyl groups converted into alkyl on transfer
Biological process: not assigned
Cellular component: not assigned

Quick links

EC 2.3.3.8: ATP citrate synthase

Reaction catalysed:
ADP + phosphate + acetyl-CoA + oxaloacetate = ATP + citrate + CoA
Systematic name:
Acetyl-CoA:oxaloacetate C-acetyltransferase ((pro-S)-carboxymethyl-forming, ADP-phosphorylating)
Alternative Name(s):
  • ATP citrate (pro-S)-lyase
  • ATP-citrate (pro-S-)-lyase
  • ATP-citric lyase
  • ATP:citrate oxaloacetate-lyase ((pro-S)-CH(2)COO(-)->acetyl-CoA) (ATP-dephosphorylating)
  • Acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP-phosphorylating)
  • Adenosine triphosphate citrate lyase
  • Citrate cleavage enzyme
  • Citrate-ATP lyase
  • Citric cleavage enzyme

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF00549
Domain description: CoA-ligase
Occurring in:
  1. ATP-citrate synthase
The deposited structure of PDB entry 5tdf contains 1 copy of Pfam domain PF00549 (CoA-ligase) in ATP-citrate synthase. Showing 1 copy in chain B.

PF02629
Domain description: CoA binding domain
Occurring in:
  1. ATP-citrate synthase
The deposited structure of PDB entry 5tdf contains 1 copy of Pfam domain PF02629 (CoA binding domain) in ATP-citrate synthase. Showing 1 copy in chain B.

PF16114
Domain description: ATP citrate lyase citrate-binding
Occurring in:
  1. ATP-citrate synthase
The deposited structure of PDB entry 5tdf contains 1 copy of Pfam domain PF16114 (ATP citrate lyase citrate-binding) in ATP-citrate synthase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR016102
Domain description: Succinyl-CoA synthetase-like
Occurring in:
  1. ATP-citrate synthase
  2. ATP-citrate synthase
IPR003781
Domain description: CoA-binding
Occurring in:
  1. ATP-citrate synthase
IPR017440
Domain description: ATP-citrate lyase/succinyl-CoA ligase, active site
Occurring in:
  1. ATP-citrate synthase
IPR033847
Domain description: ATP-citrate lyase/succinyl-CoA ligase, conserved site
Occurring in:
  1. ATP-citrate synthase
IPR005811
Domain description: ATP-citrate synthase/succinyl-CoA ligase, C-terminal domain
Occurring in:
  1. ATP-citrate synthase
IPR036291
Domain description: NAD(P)-binding domain superfamily
Occurring in:
  1. ATP-citrate synthase
IPR002020
Domain description: Citrate synthase
Occurring in:
  1. ATP-citrate synthase
IPR017866
Domain description: Succinyl-CoA synthetase, beta subunit, conserved site
Occurring in:
  1. ATP-citrate synthase
IPR032263
Domain description: ATP-citrate synthase, citrate-binding domain
Occurring in:
  1. ATP-citrate synthase
IPR005809
Domain description: Succinate--CoA ligase-like, beta subunit
Occurring in:
  1. ATP-citrate synthase

Structure domains

CATH CATH domains
3.40.50.261
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Succinyl-CoA synthetase domains
Occurring in:
  1. ATP-citrate synthase
  2. ATP-citrate synthase
The deposited structure of PDB entry 5tdf contains 1 copy of CATH domain 3.40.50.261 (Rossmann fold) in ATP-citrate synthase. Showing 1 copy in chain A.
The deposited structure of PDB entry 5tdf contains 1 copy of CATH domain 3.40.50.261 (Rossmann fold) in ATP-citrate synthase. Showing 1 copy in chain B.
3.30.470.20
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: D-amino Acid Aminotransferase; Chain A, domain 1
Homology: ATP-grasp fold, B domain
Occurring in:
  1. ATP-citrate synthase
The deposited structure of PDB entry 5tdf contains 1 copy of CATH domain 3.30.470.20 (D-amino Acid Aminotransferase; Chain A, domain 1) in ATP-citrate synthase. Showing 1 copy in chain A.
3.40.50.720
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: NAD(P)-binding Rossmann-like Domain
Occurring in:
  1. ATP-citrate synthase
The deposited structure of PDB entry 5tdf contains 1 copy of CATH domain 3.40.50.720 (Rossmann fold) in ATP-citrate synthase. Showing 1 copy in chain B.
3.30.1490.20
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Dna Ligase; domain 1
Homology: ATP-grasp fold, A domain
Occurring in:
  1. ATP-citrate synthase
The deposited structure of PDB entry 5tdf contains 1 copy of CATH domain 3.30.1490.20 (Dna Ligase; domain 1) in ATP-citrate synthase. Showing 1 copy in chain A.

Quick links