EC 2.7.11.1: Non-specific serine/threonine protein kinase
Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Systematic name:
ATP:protein phosphotransferase (non-specific)
Alternative Name(s):
- A-kinase
- AP50 kinase
- ATP-protein transphosphorylase
- Beta-IIPKC
- Beta-adrenergic receptor kinase
- CK-2
- CKI
- CKII
- Calcium-dependent protein kinase C
- Calcium/phospholipid-dependent protein kinase
- Casein kinase
- Casein kinase (phosphorylating)
- Casein kinase 2
- Casein kinase I
- Casein kinase II
- Cyclic AMP-dependent protein kinase
- Cyclic AMP-dependent protein kinase A
- Cyclic monophosphate-dependent protein kinase
- Cyclic nucleotide-dependent protein kinase
- Cyclin-dependent kinase
- Cytidine 3',5'-cyclic monophosphate-responsive protein kinase
- Dsk1
- Epsilon PKC
- Glycogen synthase A kinase
- Glycogen synthase a kinase
- Glycogen synthase kinase
- HIPK2
- Hpr kinase
- Hydroxyalkyl-protein kinase
- M phase-specific cdc2 kinase
- MAPK
- Mitogen-activated S6 kinase
- Mitogen-activated protein kinase
- P82 kinase
- PKA
- PKC
- Phosphorylase B kinase kinase
- Phosphorylase b kinase kinase
- Phosphorylase b kinase kinase
- Protein glutamyl kinase
- Protein kinase (phosphorylating)
- Protein kinase A
- Protein kinase CK2
- Protein kinase p58
- Protein phosphokinase
- Protein serine kinase
- Protein serine-threonine kinase
- Protein-aspartyl kinase
- Protein-cysteine kinase
- Protein-serine kinase
- Prp4 protein kinase
- Raf kinase
- Raf-1
- Ribosomal S6 protein kinase
- Ribosomal protein S6 kinase II
- STK32
- Serine kinase
- Serine protein kinase
- Serine(threonine) protein kinase
- Serine-specific protein kinase
- Serine/threonine protein kinase
- T-antigen kinase
- Threonine-specific protein kinase
- Twitchin kinase
- Type-2 casein kinase
- WEE1Hu
- Wee 1-like kinase
- Wee-kinase
- cAMP-dependent protein kinase
- cAMP-dependent protein kinase A
- cGMP-dependent protein kinase
EC 2.7.1.153: Phosphatidylinositol-4,5-bisphosphate 3-kinase
Reaction catalysed:
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
Systematic name:
ATP:1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 3-phosphotransferase
Alternative Name(s):
- Type I phosphoinositide 3-kinase
EC 2.7.1.137: Phosphatidylinositol 3-kinase
Reaction catalysed:
ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
Systematic name:
ATP:1-phosphatidyl-1D-myo-inositol 3-phosphotransferase
Alternative Name(s):
- 1-phosphatidylinositol 3-kinase
- PI3-kinase
- PtdIns-3-kinase
- Type I phosphatidylinositol kinase
- Type III phosphoinositide 3-kinase
- Vps34p
GO terms
Biochemical function:
- protein serine kinase activity
- 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity
- insulin receptor substrate binding
- 1-phosphatidylinositol-4-phosphate 3-kinase activity
- protein kinase activator activity
- transferase activity
- 1-phosphatidylinositol-3-kinase activity
- kinase activity
- ATP binding
- protein binding
- protein serine/threonine kinase activity
- nucleotide binding
Biological process:
- negative regulation of anoikis
- negative regulation of fibroblast apoptotic process
- positive regulation of protein localization to membrane
- response to butyrate
- autosome genomic imprinting
- regulation of actin filament organization
- energy homeostasis
- cardiac muscle cell contraction
- response to dexamethasone
- cellular response to hydrostatic pressure
- cellular response to glucose stimulus
- adipose tissue development
- cardiac muscle contraction
- relaxation of cardiac muscle
- positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
- T cell receptor signaling pathway
- positive regulation of smooth muscle cell proliferation
- phosphatidylinositol-mediated signaling
- insulin-like growth factor receptor signaling pathway
- phosphatidylinositol phosphate biosynthetic process
- endothelial cell migration
- negative regulation of neuron apoptotic process
- phosphatidylinositol 3-kinase/protein kinase B signal transduction
- regulation of cellular respiration
- anoikis
- response to L-leucine
- regulation of multicellular organism growth
- vascular endothelial growth factor signaling pathway
- phosphatidylinositol-3-phosphate biosynthetic process
- response to muscle stretch
- cellular response to insulin stimulus
- positive regulation of TOR signaling
- T cell costimulation
- negative regulation of actin filament depolymerization
- platelet activation
- actin cytoskeleton organization
- cell migration
- phosphorylation
- negative regulation of macroautophagy
- response to muscle inactivity
- response to activity
- negative regulation of gene expression
- positive regulation of lamellipodium assembly
- regulation of gene expression
- insulin receptor signaling pathway
- epidermal growth factor receptor signaling pathway
- phagocytosis
- lipid metabolic process
- glucose metabolic process
- vasculature development
- regulation of protein phosphorylation
- liver development
- angiogenesis
Cellular component:
Sequence families
Protein families (Pfam)
PF16454
Domain description:
Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
Occurring in:
Occurring in:
PF00613
Domain description:
Phosphoinositide 3-kinase family, accessory domain (PIK domain)
Occurring in:
Occurring in:
InterPro annotations
IPR000341
Domain description:
Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
Occurring in:
Occurring in:
IPR036940
Domain description:
Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily
Occurring in:
Occurring in:
IPR042236
Domain description:
Phosphoinositide 3-kinase, accessory (PIK) domain superfamily
Occurring in:
Occurring in:
CATH domain