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CRYSTAL STRUCTURE OF A HUMAN LOW MOLECULAR WEIGHT PHOSPHOTYROSYL PHOSPHATASE. IMPLICATIONS FOR SUBSTRATE SPECIFICITY

Source organism: Homo sapiens
Biochemical function: phosphatase activity
Biological process: protein dephosphorylation
Cellular component: extracellular exosome

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EC 3.1.3.48: Protein-tyrosine-phosphatase

Reaction catalysed:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Systematic name:
Protein-tyrosine-phosphate phosphohydrolase
Alternative Name(s):
  • (Phosphotyrosine)protein phosphatase
  • PPT-phosphatase
  • PTP-phosphatase
  • PTPase
  • Phosphoprotein phosphatase (phosphotyrosine)
  • Phosphotyrosine histone phosphatase
  • Phosphotyrosine phosphatase
  • Phosphotyrosine protein phosphatase
  • Phosphotyrosylprotein phosphatase
  • Protein phosphotyrosine phosphatase
  • Tyrosine O-phosphate phosphatase
  • Tyrosylprotein phosphatase

EC 3.1.3.2: Acid phosphatase

Reaction catalysed:
A phosphate monoester + H(2)O = an alcohol + phosphate
Systematic name:
Phosphate-monoester phosphohydrolase (acid optimum)
Alternative Name(s):
  • Acid monophosphatase
  • Acid nucleoside diphosphate phosphatase
  • Acid phosphohydrolase
  • Acid phosphomonoester hydrolase
  • Acid phosphomonoesterase
  • Glycerophosphatase
  • Orthophosphoric-monoester phosphohydrolase (acid optimum)
  • Phosphomonoesterase
  • Uteroferrin

GO terms

Sequence family

Pfam Protein family (Pfam)
PF01451
Domain description: Low molecular weight phosphotyrosine protein phosphatase
Occurring in:
  1. Low molecular weight phosphotyrosine protein phosphatase
The deposited structure of PDB entry 5pnt contains 1 copy of Pfam domain PF01451 (Low molecular weight phosphotyrosine protein phosphatase) in Low molecular weight phosphotyrosine protein phosphatase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002115
Domain description: Protein-tyrosine phosphatase, low molecular weight, mammalian
Occurring in:
  1. Low molecular weight phosphotyrosine protein phosphatase
IPR017867
Domain description: Protein-tyrosine phosphatase, low molecular weight
Occurring in:
  1. Low molecular weight phosphotyrosine protein phosphatase
IPR023485
Domain description: Phosphotyrosine protein phosphatase I
Occurring in:
  1. Low molecular weight phosphotyrosine protein phosphatase
IPR036196
Domain description: Phosphotyrosine protein phosphatase I superfamily
Occurring in:
  1. Low molecular weight phosphotyrosine protein phosphatase

Structure domain

CATH CATH domain
3.40.50.2300
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Rossmann fold
Occurring in:
  1. Low molecular weight phosphotyrosine protein phosphatase
The deposited structure of PDB entry 5pnt contains 1 copy of CATH domain 3.40.50.2300 (Rossmann fold) in Low molecular weight phosphotyrosine protein phosphatase. Showing 1 copy in chain A.
SCOP SCOP annotation
52789
Class: Alpha and beta proteins (a/b)
Fold: Phosphotyrosine protein phosphatases I-like
Superfamily: Phosphotyrosine protein phosphatases I
Occurring in:
  1. Low molecular weight phosphotyrosine protein phosphatase
The deposited structure of PDB entry 5pnt contains 1 copy of SCOP domain 52789 (Low-molecular-weight phosphotyrosine protein phosphatases) in Low molecular weight phosphotyrosine protein phosphatase. Showing 1 copy in chain A.

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