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Crystal Structure of Factor VIIa in complex with 1H-benzimidazol-2-amine

Source organism: Homo sapiens
Biochemical function: serine-type endopeptidase activity
Biological process: proteolysis
Cellular component: not assigned

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EC 3.4.21.21: Coagulation factor VIIa

Reaction catalysed:
Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa.
Alternative Name(s):
  • Activated blood coagulation factor VII
  • Blood-coagulation factor VIIa

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF00089
Domain description: Trypsin
Occurring in:
  1. Factor VII heavy chain
The deposited structure of PDB entry 5par contains 1 copy of Pfam domain PF00089 (Trypsin) in Factor VII heavy chain. Showing 1 copy in chain B [auth C].

PF14670
Domain description: Coagulation Factor Xa inhibitory site
Occurring in:
  1. Factor VII light chain
The deposited structure of PDB entry 5par contains 1 copy of Pfam domain PF14670 (Coagulation Factor Xa inhibitory site) in Factor VII light chain. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001314
Domain description: Peptidase S1A, chymotrypsin family
Occurring in:
  1. Factor VII heavy chain
IPR001254
Domain description: Serine proteases, trypsin domain
Occurring in:
  1. Factor VII heavy chain
IPR043504
Domain description: Peptidase S1, PA clan, chymotrypsin-like fold
Occurring in:
  1. Factor VII heavy chain
IPR033116
Domain description: Serine proteases, trypsin family, serine active site
Occurring in:
  1. Factor VII heavy chain
IPR018114
Domain description: Serine proteases, trypsin family, histidine active site
Occurring in:
  1. Factor VII heavy chain
IPR009003
Domain description: Peptidase S1, PA clan
Occurring in:
  1. Factor VII heavy chain

Structure domains

CATH CATH domains
2.40.10.10
Class: Mainly Beta
Architecture: Beta Barrel
Topology: Thrombin, subunit H
Homology: Trypsin-like serine proteases
Occurring in:
  1. Factor VII heavy chain
The deposited structure of PDB entry 5par contains 2 copies of CATH domain 2.40.10.10 (Thrombin, subunit H) in Factor VII heavy chain. Showing 2 copies in chain B [auth C].
2.10.25.10
Class: Mainly Beta
Architecture: Ribbon
Topology: Laminin
Homology: Laminin
Occurring in:
  1. Factor VII light chain
The deposited structure of PDB entry 5par contains 1 copy of CATH domain 2.10.25.10 (Laminin) in Factor VII light chain. Showing 1 copy in chain A.

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