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HUMAN PHENYLALANINE HYDROXYLASE CATALYTIC DOMAIN DIMER WITH BOUND DOPAMINE INHIBITOR

X-ray diffraction
2.1Å resolution
PDB entry 5pah coloured by chain, front view.
PDB entry 5pah coloured by chain, side view.
PDB entry 5pah coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Phenylalanine-4-hydroxylase
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Multimeric state: monomeric
Accessible surface area: 14327.42 Å2
Buried surface area: 583.63 Å2
Dissociation area: 246.03 Å2
Dissociation energy (ΔGdiss): 7.12 kcal/mol
Dissociation entropy (TΔSdiss): 3.1 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-132486

Macromolecules

Phenylalanine-4-hydroxylase
Chain: A
Length: 308 amino acids
Theoretical weight: 35.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P00439 (Residues: 117-424; Coverage: 68%)
Gene name: PAH
Pfam: Biopterin-dependent aromatic amino acid hydroxylase
InterPro:
CATH: Aromatic amino acid hydroxylase
SCOP: Aromatic aminoacid monoxygenases, catalytic and oligomerization domains
Phenylalanine-4-hydroxylase in PDB entry 5pah, assembly 1, front view.
Phenylalanine-4-hydroxylase in PDB entry 5pah, assembly 1, side view.
Phenylalanine-4-hydroxylase in PDB entry 5pah, assembly 1, top view.
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