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Near-atomic resolution fibril structure of complete amyloid-beta(1-42) by cryo-EM

Electron Microscopy
4Å resolution
PDB entry 5oqv coloured by chain, front view.
PDB entry 5oqv coloured by chain, side view.
PDB entry 5oqv coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo nonamer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Soluble APP-beta
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Multimeric state: homo nonamer
Accessible surface area: 15810.29 Å2
Buried surface area: 29415.71 Å2
Dissociation area: 1,163.12 Å2
Dissociation energy (ΔGdiss): 0.25 kcal/mol
Dissociation entropy (TΔSdiss): 12.18 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-138405

Macromolecules

Amyloid-beta protein 42
Chains: A, B, C, D, E, F, G, H, I
Length: 42 amino acids
Theoretical weight: 4.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05067 (Residues: 672-713; Coverage: 6%)
Gene names: A4, AD1, APP
Pfam: Beta-amyloid peptide (beta-APP)
InterPro:
Amyloid-beta protein 42 in PDB entry 5oqv, assembly 1, front view.
Amyloid-beta protein 42 in PDB entry 5oqv, assembly 1, side view.
Amyloid-beta protein 42 in PDB entry 5oqv, assembly 1, top view.
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