› › Function and Biology

Crystal structure of human SHIP2 Phosphatase-C2 double mutant F593D/L597D

Source organism: Homo sapiens
Biochemical function: phosphatase activity
Biological process: phosphatidylinositol dephosphorylation
Cellular component: not assigned

Quick links

EC 3.1.3.86: Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase

Reaction catalysed:
1-phosphatidyl-1D-myo-inositol 3,4,5-triphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 3,4-diphosphate + phosphate
Systematic name:
1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 5-phosphohydrolase
Alternative Name(s):
  • P150Ship
  • SHIP
  • SHIP1
  • SHIP2

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

InterPro InterPro annotations
IPR036691
Domain description: Endonuclease/exonuclease/phosphatase superfamily
Occurring in:
  1. Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
IPR005135
Domain description: Endonuclease/exonuclease/phosphatase
Occurring in:
  1. Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
IPR000300
Domain description: Inositol polyphosphate-related phosphatase
Occurring in:
  1. Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

Quick links