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Putative active dimeric state of GHR transmembrane domain

Solution NMR
PDB entry 5oek coloured by chain, ensemble of 20 models, front view.
PDB entry 5oek coloured by chain, ensemble of 20 models, side view.
PDB entry 5oek coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Growth hormone-binding protein
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Multimeric state: homo dimer
Accessible surface area: 9386.24 Å2
Buried surface area: 601.62 Å2
Dissociation area: 300.81 Å2
Dissociation energy (ΔGdiss): -0.16 kcal/mol
Dissociation entropy (TΔSdiss): 9.89 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-145518

Macromolecules

Growth hormone-binding protein
Chains: A, B
Length: 43 amino acids
Theoretical weight: 5.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
UniProt:
  • Canonical: P10912 (Residues: 254-294; Coverage: 7%)
Gene name: GHR
Growth hormone-binding protein in PDB entry 5oek, assembly 1, front view.
Growth hormone-binding protein in PDB entry 5oek, assembly 1, side view.
Growth hormone-binding protein in PDB entry 5oek, assembly 1, top view.
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