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'Porcine (Sus scrofa) Major Histocompatibility Complex, class I, with human beta2 micro globulin, presenting EFEDLTFLA

X-ray diffraction
1.57Å resolution
PDB entry 5nq3 coloured by chain, front view.
PDB entry 5nq3 coloured by chain, side view.
PDB entry 5nq3 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1
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Multimeric state: hetero trimer
Accessible surface area: 19106.64 Å2
Buried surface area: 4863.86 Å2
Dissociation area: 829.25 Å2
Dissociation energy (ΔGdiss): 10.39 kcal/mol
Dissociation entropy (TΔSdiss): 7.37 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-109391
Assembly 2 (preferred)
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Multimeric state: hetero trimer
Accessible surface area: 19133.83 Å2
Buried surface area: 5433.01 Å2
Dissociation area: 837.6 Å2
Dissociation energy (ΔGdiss): 10.17 kcal/mol
Dissociation entropy (TΔSdiss): 7.42 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-109391

Macromolecules

Ig-like domain-containing protein
Chains: A, D
Length: 276 amino acids
Theoretical weight: 31.68 KDa
Source organism: Sus scrofa
Expression system: Escherichia coli
UniProt:
  • Canonical: B1PJV3 (Residues: 22-296; Coverage: 81%)
Gene name: SLA-1
Pfam:
InterPro:
CATH:
Ig-like domain-containing protein in PDB entry 5nq3, assembly 2, front view.
Ig-like domain-containing protein in PDB entry 5nq3, assembly 2, side view.
Ig-like domain-containing protein in PDB entry 5nq3, assembly 2, top view.
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Beta-2-microglobulin
Chains: B, E
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Pfam: Immunoglobulin C1-set domain
InterPro:
CATH: Immunoglobulins
Beta-2-microglobulin in PDB entry 5nq3, assembly 2, front view.
Beta-2-microglobulin in PDB entry 5nq3, assembly 2, side view.
Beta-2-microglobulin in PDB entry 5nq3, assembly 2, top view.
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Nucleoprotein
Chains: C, F
Length: 9 amino acids
Theoretical weight: 1.08 KDa
Source organism: unidentified influenza virus
Expression system: Not provided
UniProt:
  • Canonical: P03466 (Residues: 252-260; Coverage: 2%)
Gene name: NP
Nucleoprotein in PDB entry 5nq3, assembly 2, front view.
Nucleoprotein in PDB entry 5nq3, assembly 2, side view.
Nucleoprotein in PDB entry 5nq3, assembly 2, top view.
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