EC 2.7.11.1: Non-specific serine/threonine protein kinase
Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Systematic name:
ATP:protein phosphotransferase (non-specific)
Alternative Name(s):
- A-kinase
- AP50 kinase
- ATP-protein transphosphorylase
- Beta-IIPKC
- Beta-adrenergic receptor kinase
- CK-2
- CKI
- CKII
- Calcium-dependent protein kinase C
- Calcium/phospholipid-dependent protein kinase
- Casein kinase
- Casein kinase (phosphorylating)
- Casein kinase 2
- Casein kinase I
- Casein kinase II
- Cyclic AMP-dependent protein kinase
- Cyclic AMP-dependent protein kinase A
- Cyclic monophosphate-dependent protein kinase
- Cyclic nucleotide-dependent protein kinase
- Cyclin-dependent kinase
- Cytidine 3',5'-cyclic monophosphate-responsive protein kinase
- Dsk1
- Epsilon PKC
- Glycogen synthase A kinase
- Glycogen synthase a kinase
- Glycogen synthase kinase
- HIPK2
- Hpr kinase
- Hydroxyalkyl-protein kinase
- M phase-specific cdc2 kinase
- MAPK
- Mitogen-activated S6 kinase
- Mitogen-activated protein kinase
- P82 kinase
- PKA
- PKC
- Phosphorylase B kinase kinase
- Phosphorylase b kinase kinase
- Phosphorylase b kinase kinase
- Protein glutamyl kinase
- Protein kinase (phosphorylating)
- Protein kinase A
- Protein kinase CK2
- Protein kinase p58
- Protein phosphokinase
- Protein serine kinase
- Protein serine-threonine kinase
- Protein-aspartyl kinase
- Protein-cysteine kinase
- Protein-serine kinase
- Prp4 protein kinase
- Raf kinase
- Raf-1
- Ribosomal S6 protein kinase
- Ribosomal protein S6 kinase II
- STK32
- Serine kinase
- Serine protein kinase
- Serine(threonine) protein kinase
- Serine-specific protein kinase
- Serine/threonine protein kinase
- T-antigen kinase
- Threonine-specific protein kinase
- Twitchin kinase
- Type-2 casein kinase
- WEE1Hu
- Wee 1-like kinase
- Wee-kinase
- cAMP-dependent protein kinase
- cAMP-dependent protein kinase A
- cGMP-dependent protein kinase
GO terms
Biochemical function:
- protein serine kinase activity
- protein-containing complex binding
- identical protein binding
- histone H2AXS139 kinase activity
- 1-phosphatidylinositol-3-kinase activity
- kinase activity
- ATP binding
- protein binding
- DNA-dependent protein kinase activity
- protein serine/threonine kinase activity
- protein kinase activity
- DNA binding
Biological process:
- regulation of autophagosome assembly
- positive regulation of telomerase catalytic core complex assembly
- positive regulation of telomere maintenance via telomere lengthening
- negative regulation of telomere capping
- negative regulation of TORC1 signaling
- regulation of microglial cell activation
- positive regulation of DNA catabolic process
- regulation of signal transduction by p53 class mediator
- regulation of cellular response to heat
- establishment of protein-containing complex localization to telomere
- establishment of RNA localization to telomere
- replicative senescence
- cellular senescence
- regulation of cellular response to stress
- regulation of primary metabolic process
- cellular response to nitrosative stress
- cellular response to X-ray
- cellular response to gamma radiation
- cellular response to ionizing radiation
- cellular response to retinoic acid
- histone mRNA catabolic process
- chromosome organization involved in meiotic cell cycle
- regulation of telomerase activity
- regulation of cell cycle
- neuron apoptotic process
- obsolete regulation of nitrogen compound metabolic process
- oocyte development
- thymus development
- protein autophosphorylation
- positive regulation of transcription by RNA polymerase II
- positive regulation of cell adhesion
- meiotic telomere clustering
- positive regulation of neuron apoptotic process
- positive regulation of DNA damage response, signal transduction by p53 class mediator
- positive regulation of apoptotic process
- regulation of apoptotic process
- signal transduction in response to DNA damage
- lipoprotein catabolic process
- peptidyl-serine autophosphorylation
- phosphatidylinositol-3-phosphate biosynthetic process
- multicellular organism growth
- cellular response to reactive oxygen species
- V(D)J recombination
- positive regulation of telomere maintenance via telomerase
- regulation of telomere maintenance via telomerase
- negative regulation of B cell proliferation
- positive regulation of cell migration
- peptidyl-serine phosphorylation
- positive regulation of gene expression
- regulation of autophagy
- response to ionizing radiation
- post-embryonic development
- intrinsic apoptotic signaling pathway in response to DNA damage
- female gonad development
- determination of adult lifespan
- heart development
- brain development
- female gamete generation
- signal transduction
- female meiotic nuclear division
- male meiotic nuclear division
- reciprocal meiotic recombination
- mitotic G2 DNA damage checkpoint signaling
- mitotic spindle assembly checkpoint signaling
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
- DNA damage response
- protein phosphorylation
- chromatin remodeling
- double-strand break repair via nonhomologous end joining
- double-strand break repair
- DNA repair
- immune system process
- pre-B cell allelic exclusion
- somitogenesis
- response to hypoxia
- ovarian follicle development
- DNA double-strand break processing
- double-strand break repair via homologous recombination
- telomere maintenance
- pexophagy
- DNA damage checkpoint signaling
Cellular component:
Sequence families
Protein families (Pfam)
InterPro annotations
IPR036940
Domain description:
Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily
Occurring in:
Occurring in: