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Complement factor D

X-ray diffraction
1.33Å resolution
PDB entry 5nb7 coloured by chain, front view.
PDB entry 5nb7 coloured by chain, side view.
PDB entry 5nb7 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Complement factor D
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Multimeric state: monomeric
Accessible surface area: 10043.93 Å2
Buried surface area: 418.19 Å2
Dissociation area: 116.38 Å2
Dissociation energy (ΔGdiss): -1.43 kcal/mol
Dissociation entropy (TΔSdiss): 0.12 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-133224

Macromolecules

Complement factor D
Chain: A
Length: 230 amino acids
Theoretical weight: 24.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P00746 (Residues: 26-253; Coverage: 98%)
Gene names: CFD, DF, PFD
Pfam: Trypsin
InterPro:
CATH: Trypsin-like serine proteases
Complement factor D in PDB entry 5nb7, assembly 1, front view.
Complement factor D in PDB entry 5nb7, assembly 1, side view.
Complement factor D in PDB entry 5nb7, assembly 1, top view.
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