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Crystal structure of Smad4-MH1 bound to the GGCT site.

X-ray diffraction
2.98Å resolution
PDB entry 5mez coloured by chain, front view.
PDB entry 5mez coloured by chain, side view.
PDB entry 5mez coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule
1 distinct DNA molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Mothers against decapentaplegic homolog 4 and DNA
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Multimeric state: hetero tetramer
Accessible surface area: 17538.42 Å2
Buried surface area: 3562.36 Å2
Dissociation area: 490.86 Å2
Dissociation energy (ΔGdiss): -3.7 kcal/mol
Dissociation entropy (TΔSdiss): 11.48 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-119020

Macromolecules

Mothers against decapentaplegic homolog 4
Chains: A, B
Length: 135 amino acids
Theoretical weight: 15.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13485 (Residues: 10-140; Coverage: 24%)
Gene names: DPC4, MADH4, SMAD4
Pfam: MH1 domain
InterPro:
CATH: SMAD MH1 domain
Mothers against decapentaplegic homolog 4 in PDB entry 5mez, assembly 1, front view.
Mothers against decapentaplegic homolog 4 in PDB entry 5mez, assembly 1, side view.
Mothers against decapentaplegic homolog 4 in PDB entry 5mez, assembly 1, top view.
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DNA chains D, E
Name: DNA (5'-D(P*GP*CP*AP*GP*GP*CP*TP*AP*GP*CP*CP*TP*GP*CP*A)-3')
Representative chains: D, E
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 16 nucleotides
Theoretical weight: 4.9 KDa
DNA (5'-D(P*GP*CP*AP*GP*GP*CP*TP*AP*GP*CP*CP*TP*GP*CP*A)-3') in PDB entry 5mez, assembly 1, front view.
DNA (5'-D(P*GP*CP*AP*GP*GP*CP*TP*AP*GP*CP*CP*TP*GP*CP*A)-3') in PDB entry 5mez, assembly 1, side view.
DNA (5'-D(P*GP*CP*AP*GP*GP*CP*TP*AP*GP*CP*CP*TP*GP*CP*A)-3') in PDB entry 5mez, assembly 1, top view.
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