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Comment on "Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2".

Zhang Y, Justin N, Wilson JR, Gamblin SJ
Science 354 1543 (2016)
Cited: 3 times
EuropePMC logo PMID: 28008037

Abstract

Jiao and Liu (Research Articles, 16 October 2015, aac4383) reported the crystal structure of the protein complex polycomb repressive complex 2 from Chaetomium thermophilum This landmark structure has brought invaluable insights into the activation mechanism of this essential methyltransferase. However, the analysis of the x-ray data discussed below suggests that the description of oncogenic H3K27M peptide binding to the active site is incorrect.

Reviews citing this publication (2)

  1. Structure, mechanism, and regulation of polycomb-repressive complex 2. Moritz LE, Trievel RC. J. Biol. Chem. 293 13805-13814 (2018)
  2. Functions of Polycomb Proteins on Active Targets. Giner-Laguarda N, Vidal M. Epigenomes 4 17 (2020)

Articles citing this publication (1)

  1. Acute Treatment with Nicotinamide Riboside Chloride Reduces Hippocampal Damage and Preserves the Cognitive Function of Mice with Ischemic Injury. Cheng YH, Zhao JH, Zong WF, Wei XJ, Xu Z, Yuan Y, Jiang YF, Luo X, Wang W, Qu WS. Neurochem Res 47 2244-2253 (2022)


Related citations provided by authors (1)

  1. Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2.. Jiao L, Liu X Science 350 aac4383 (2015)

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