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The structure of INI1/hSNF5 RPT1 and its interactions with the c-MYC:MAX heterodimer provide insights into the interplay between MYC and the SWI/SNF chromatin remodeling complex.

Sammak S, Allen MD, Hamdani N, Bycroft M, Zinzalla G
FEBS J 285 4165-4180 (2018)
Cited: 22 times
EuropePMC logo PMID: 30222246

Abstract

c-MYC and the SWI/SNF chromatin remodeling complex act as master regulators of transcription, and play a key role in human cancer. Although they are known to interact, the molecular details of their interaction are lacking. We have determined the structure of the RPT1 region of the INI1/hSNF5/BAF47/SMARCB1 subunit of the SWI/SNF complex that acts as a c-MYC-binding domain, and have localized the interaction regions on both INI1 and on the c-MYC:MAX heterodimer. c-MYC interacts with a highly conserved groove on INI1, while INI1 binds to the c-MYC helix-loop-helix region. The binding site overlaps with the c-MYC DNA-binding region, and we show that binding of INI1 and E-box DNA to c-MYC:MAX are mutually exclusive.

Articles - 5l7a mentioned but not cited (4)

  1. Self-association of a highly charged arginine-rich cell-penetrating peptide. Tesei G, Vazdar M, Jensen MR, Cragnell C, Mason PE, Heyda J, Skepö M, Jungwirth P, Lund M. Proc Natl Acad Sci U S A 114 11428-11433 (2017)
  2. The structure of INI1/hSNF5 RPT1 and its interactions with the c-MYC:MAX heterodimer provide insights into the interplay between MYC and the SWI/SNF chromatin remodeling complex. Sammak S, Allen MD, Hamdani N, Bycroft M, Zinzalla G. FEBS J 285 4165-4180 (2018)
  3. INI1/SMARCB1 Rpt1 domain mimics TAR RNA in binding to integrase to facilitate HIV-1 replication. Dixit U, Bhutoria S, Wu X, Qiu L, Spira M, Mathew S, Harris R, Adams LJ, Cahill S, Pathak R, Rajesh Kumar P, Nguyen M, Acharya SA, Brenowitz M, Almo SC, Zou X, Steven AC, Cowburn D, Girvin M, Kalpana GV. Nat Commun 12 2743 (2021)
  4. A Coil-to-Helix Transition Serves as a Binding Motif for hSNF5 and BAF155 Interaction. Han J, Kim I, Park JH, Yun JH, Joo K, Kim T, Park GY, Ryu KS, Ko YJ, Mizutani K, Park SY, Seong RH, Lee J, Suh JY, Lee W. Int J Mol Sci 21 E2452 (2020)


Reviews citing this publication (9)

  1. Therapeutic targeting of "undruggable" MYC. Llombart V, Mansour MR. EBioMedicine 75 103756 (2022)
  2. Structural and Biophysical Insights into the Function of the Intrinsically Disordered Myc Oncoprotein. Beaulieu ME, Castillo F, Soucek L. Cells 9 E1038 (2020)
  3. Emerging role of SWI/SNF complex deficiency as a target of immune checkpoint blockade in human cancers. Zhou M, Yuan J, Deng Y, Fan X, Shen J. Oncogenesis 10 3 (2021)
  4. MYC: a complex problem. Das SK, Lewis BA, Levens D. Trends Cell Biol 33 235-246 (2023)
  5. Emerging Themes in Mechanisms of Tumorigenesis by SWI/SNF Subunit Mutation. Jones CA, Tansey WP, Weissmiller AM. Epigenet Insights 15 25168657221115656 (2022)
  6. SMARCB1-Deficient Cancers: Novel Molecular Insights and Therapeutic Vulnerabilities. Cooper GW, Hong AL. Cancers (Basel) 14 3645 (2022)
  7. SWI/SNF complexes in hematological malignancies: biological implications and therapeutic opportunities. Andrades A, Peinado P, Alvarez-Perez JC, Sanjuan-Hidalgo J, García DJ, Arenas AM, Matia-González AM, Medina PP. Mol Cancer 22 39 (2023)
  8. Biophysical insights into glucose-dependent transcriptional regulation by PDX1. Usher ET, Showalter SA. J Biol Chem 298 102623 (2022)
  9. Epigenetic Regulation in Primary CNS Tumors: An Opportunity to Bridge Old and New WHO Classifications. Dang DD, Rosenblum JS, Shah AH, Zhuang Z, Doucet-O'Hare TT. Cancers (Basel) 15 2511 (2023)

Articles citing this publication (9)

  1. MYC protein stability is negatively regulated by BRD4. Devaiah BN, Mu J, Akman B, Uppal S, Weissman JD, Cheng D, Baranello L, Nie Z, Levens D, Singer DS. Proc Natl Acad Sci U S A 117 13457-13467 (2020)
  2. Architecture of the chromatin remodeler RSC and insights into its nucleosome engagement. Patel AB, Moore CM, Greber BJ, Luo J, Zukin SA, Ranish J, Nogales E. Elife 8 e54449 (2019)
  3. Inhibition of MYC by the SMARCB1 tumor suppressor. Weissmiller AM, Wang J, Lorey SL, Howard GC, Martinez E, Liu Q, Tansey WP. Nat Commun 10 2014 (2019)
  4. cBAF complex components and MYC cooperate early in CD8+ T cell fate. Guo A, Huang H, Zhu Z, Chen MJ, Shi H, Yuan S, Sharma P, Connelly JP, Liedmann S, Dhungana Y, Li Z, Haydar D, Yang M, Beere H, Yustein JT, DeRenzo C, Pruett-Miller SM, Crawford JC, Krenciute G, Roberts CWM, Chi H, Green DR. Nature 607 135-141 (2022)
  5. Crystal Structures and Nuclear Magnetic Resonance Studies of the Apo Form of the c-MYC:MAX bHLHZip Complex Reveal a Helical Basic Region in the Absence of DNA. Sammak S, Hamdani N, Gorrec F, Allen MD, Freund SMV, Bycroft M, Zinzalla G. Biochemistry 58 3144-3154 (2019)
  6. SMARCB1 deletion in atypical teratoid rhabdoid tumors results in human endogenous retrovirus K (HML-2) expression. Doucet-O'Hare TT, DiSanza BL, DeMarino C, Atkinson AL, Rosenblum JS, Henderson LJ, Johnson KR, Kowalak J, Garcia-Montojo M, Allen SJ, Orr BA, Santi M, Wang T, Fathi S, Lee MH, Sampson K, Li W, Zhuang Z, Nath A. Sci Rep 11 12893 (2021)
  7. Structure of the BRK domain of the SWI/SNF chromatin remodeling complex subunit BRG1 reveals a potential role in protein-protein interactions. Allen MD, Bycroft M, Zinzalla G. Protein Sci 29 1047-1053 (2020)
  8. PHF10 subunit of PBAF complex mediates transcriptional activation by MYC. Soshnikova NV, Tatarskiy EV, Tatarskiy VV, Klimenko NS, Shtil AA, Nikiforov MA, Georgieva SG. Oncogene 40 6071-6080 (2021)
  9. Biophysical and Structural Methods to Study the bHLHZip Region of Human c-MYC. Zinzalla G. Methods Mol Biol 2318 21-43 (2021)


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