PDB 5l2k structure summary ‹ Protein Data Bank in Europe (PDBe)

Function and Biology Details

Biochemical function:

protein homodimerization activity

Biological process:

negative regulation of forebrain neuron differentiation

Cellular component:

HFE-transferrin receptor complex

Sequence domains:

4 more domains

Structure analysis Details

Assemblies composition:

hetero tetramer (preferred)
hetero hexadecamer

PDBe Complex ID:

PDB-CPX-230924 (preferred)

Entry contents:

4 distinct polypeptide molecules

Macromolecules (4 distinct):

T-cell surface glycoprotein CD1b Chain: A

Molecule details ›

Chain: A
Length: 300 amino acids
Theoretical weight: 33.49 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:

Canonical: P29016 (Residues: 20-296; Coverage: 88%)

Gene name: CD1B
Sequence domains:

Structure domains:

Beta-2-microglobulin Chain: B

Molecule details ›

Chain: B
Length: 98 amino acids
Theoretical weight: 11.62 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:

Canonical: P61769 (Residues: 21-118; Coverage: 99%)

Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins

GEM42 TCR alpha chain Chain: D

Molecule details ›

Chain: D
Length: 204 amino acids
Theoretical weight: 22.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)

Structure domains: Immunoglobulins

GEM42 TCR beta chain Chain: E

Molecule details ›

Chain: E
Length: 243 amino acids
Theoretical weight: 27.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)

Structure domains: Immunoglobulins