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human POGLUT1 in complex with Factor VII EGF1 and UDP

X-ray diffraction
1.45Å resolution
PDB entry 5l0s coloured by chain, front view.
PDB entry 5l0s coloured by chain, side view.
PDB entry 5l0s coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Coagulation factor VIIa complex and Protein O-glucosyltransferase 1
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Multimeric state: hetero dimer
Accessible surface area: 17781.47 Å2
Buried surface area: 3759.73 Å2
Dissociation area: 961.76 Å2
Dissociation energy (ΔGdiss): 1.84 kcal/mol
Dissociation entropy (TΔSdiss): 10.14 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-140357

Macromolecules

Protein O-glucosyltransferase 1
Chain: A
Length: 357 amino acids
Theoretical weight: 42.08 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8NBL1 (Residues: 29-385; Coverage: 97%)
Gene names: C3orf9, CLP46, KTELC1, MDS010, MDSRP, POGLUT1, UNQ490/PRO1006
Pfam: Glycosyl transferase family 90
InterPro: Glycosyl transferase CAP10 domain
Protein O-glucosyltransferase 1 in PDB entry 5l0s, assembly 1, front view.
Protein O-glucosyltransferase 1 in PDB entry 5l0s, assembly 1, side view.
Protein O-glucosyltransferase 1 in PDB entry 5l0s, assembly 1, top view.
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Factor VII light chain
Chain: B
Length: 42 amino acids
Theoretical weight: 4.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P08709 (Residues: 105-145; Coverage: 9%)
Gene name: F7
Pfam: EGF-like domain
InterPro:
Factor VII light chain in PDB entry 5l0s, assembly 1, front view.
Factor VII light chain in PDB entry 5l0s, assembly 1, side view.
Factor VII light chain in PDB entry 5l0s, assembly 1, top view.
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