EC 3.4.19.12: Ubiquitinyl hydrolase 1
Reaction catalysed:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Systematic name:
-
Alternative Name(s):
- Ubiquitin C-terminal hydrolase
- Ubiquitin carboxyl-terminal hydrolase
- Ubiquitin thiolesterase
- Yeast ubiquitin hydrolase
GO terms
Biochemical function:
Biological process:
Cellular component:
- not assigned
Protein families (Pfam)![The deposited structure of PDB entry 5kyc contains 1 copy of Pfam domain PF00240 (Ubiquitin family) in Ubiquitin. Showing 1 copy in chain B [auth C].](https://www.ebi.ac.uk/pdbe/static/entry/5kyc_2_C_Pfam_PF00240_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>5kyc</span> contains 1 copy of Pfam domain <span class='highlight'>PF00240 (Ubiquitin family)</span> in <span class='highlight'>Ubiquitin</span>. Showing 1 copy in chain <span class='highlight'>B [auth C]</span>.")
![The deposited structure of PDB entry 5kyc contains 1 copy of Pfam domain PF00443 (Ubiquitin carboxyl-terminal hydrolase) in Ubiquitin carboxyl-terminal hydrolase 7. Showing 1 copy in chain A [auth B].](https://www.ebi.ac.uk/pdbe/static/entry/5kyc_1_B_Pfam_PF00443_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>5kyc</span> contains 1 copy of Pfam domain <span class='highlight'>PF00443 (Ubiquitin carboxyl-terminal hydrolase)</span> in <span class='highlight'>Ubiquitin carboxyl-terminal hydrolase 7</span>. Showing 1 copy in chain <span class='highlight'>A [auth B]</span>.")
InterPro annotations
CATH domain![The deposited structure of PDB entry 5kyc contains 1 copy of CATH domain 2.20.210.10 (ubp-family deubiquitinating enzyme fold) in Ubiquitin carboxyl-terminal hydrolase 7. Showing 1 copy in chain A [auth B].](https://www.ebi.ac.uk/pdbe/static/entry/5kyc_1_B_CATH_2.20.210.10_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>5kyc</span> contains 1 copy of CATH domain <span class='highlight'>2.20.210.10 (ubp-family deubiquitinating enzyme fold)</span> in <span class='highlight'>Ubiquitin carboxyl-terminal hydrolase 7</span>. Showing 1 copy in chain <span class='highlight'>A [auth B]</span>.")