› 5kj4

X-ray diffraction
3.35Å resolution

Crystal Structure of Mouse Protocadherin-15 EC9-10

Released:
DOI: 10.2210/pdb5kj4/pdb
PDB entry 5kj4 coloured by chain, front view.
PDB entry 5kj4 coloured by chain, side view.
PDB entry 5kj4 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
An elastic element in the protocadherin-15 tip link of the inner ear.
Araya-Secchi R, Neel BL, Sotomayor M
Nat Commun 7 13458 (2016)
PMID: 27857071

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189381 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protocadherin-15 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 234 amino acids
Theoretical weight: 25.97 KDa
Source organism: Mus musculus
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
UniProt:
  • Canonical: Q99PJ1 (Residues: 924-1149; Coverage: 12%)
Gene name: Pcdh15
Sequence domains: Cadherin domain
Structure domains: Cadherins

Ligands and Environments

1 bound ligand:
Ligand CA 12 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P31
Unit cell:
a: 143.541Å b: 143.541Å c: 95.599Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.159 0.158 0.196
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'

Quick links

Citations

8 review citations

Evolution and diversity of cadherins and catenins.
Gul et al. (2017)
7 more

1 mention without citation

An elastic element in the protocadherin-15 tip link of the inner ear.
Araya-Secchi et al. (2016)