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Crystal structure of JAK1 in complex with ADP

X-ray diffraction
2.47Å resolution
PDB entry 5khw coloured by chain, front view.
PDB entry 5khw coloured by chain, side view.
PDB entry 5khw coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Tyrosine-protein kinase JAK1
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Multimeric state: monomeric
PDBe Complex ID: PDB-CPX-149968
Assembly 2
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Assembly Name: Tyrosine-protein kinase JAK1
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Multimeric state: monomeric
PDBe Complex ID: PDB-CPX-149968

Macromolecules

Tyrosine-protein kinase JAK1
Chains: A, B
Length: 316 amino acids
Theoretical weight: 36.42 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P23458 (Residues: 841-1154; Coverage: 27%)
Gene names: JAK1, JAK1A, JAK1B
Pfam: Protein tyrosine and serine/threonine kinase
InterPro:
CATH:
Tyrosine-protein kinase JAK1 in PDB entry 5khw, assembly 1, front view.
Tyrosine-protein kinase JAK1 in PDB entry 5khw, assembly 1, side view.
Tyrosine-protein kinase JAK1 in PDB entry 5khw, assembly 1, top view.
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