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Crystal structure of EBV tegument protein BNRF1 in complex with histone chaperone DAXX and histones H3.3-H4

Source organisms:
Biochemical function: protein heterodimerization activity
Biological process: telomere organization
Cellular component: extracellular exosome

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF12818
Domain description: dsDNA viral tegument protein
Occurring in:
  1. Major tegument protein

PF20920
Domain description: Death domain-associated protein 6, histone binding domain
Occurring in:
  1. Death domain-associated protein 6
The deposited structure of PDB entry 5kdm contains 1 copy of Pfam domain PF20920 (Death domain-associated protein 6, histone binding domain) in Death domain-associated protein 6. Showing 1 copy in chain C.

PF15511
Domain description: Centromere kinetochore component CENP-T histone fold
Occurring in:
  1. Histone H4
The deposited structure of PDB entry 5kdm contains 1 copy of Pfam domain PF15511 (Centromere kinetochore component CENP-T histone fold) in Histone H4. Showing 1 copy in chain B.

PF00125
Domain description: Core histone H2A/H2B/H3/H4
Occurring in:
  1. Histone H3.3
The deposited structure of PDB entry 5kdm contains 1 copy of Pfam domain PF00125 (Core histone H2A/H2B/H3/H4) in Histone H3.3. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000164
Domain description: Histone H3/CENP-A
Occurring in:
  1. Histone H3.3
IPR001951
Domain description: Histone H4
Occurring in:
  1. Histone H4
IPR009072
Domain description: Histone-fold
Occurring in:
  1. Histone H3.3
  2. Histone H4
IPR024346
Domain description: Tegument protein, herpes virus, N-terminal domain
Occurring in:
  1. Major tegument protein
IPR046378
Domain description: Daxx, histone-binding domain
Occurring in:
  1. Death domain-associated protein 6
IPR046426
Domain description: Daxx, histone-binding domain superfamily
Occurring in:
  1. Death domain-associated protein 6
IPR035425
Domain description: CENP-T/Histone H4, histone fold
Occurring in:
  1. Histone H4
IPR004823
Domain description: TATA box binding protein associated factor (TAF), histone-like fold domain
Occurring in:
  1. Histone H4
IPR019809
Domain description: Histone H4, conserved site
Occurring in:
  1. Histone H4
IPR007125
Domain description: Histone H2A/H2B/H3
Occurring in:
  1. Histone H3.3

Structure domains

CATH CATH domains
1.10.20.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Histone, subunit A
Homology: Histone, subunit A
Occurring in:
  1. Histone H3.3
  2. Histone H4
The deposited structure of PDB entry 5kdm contains 1 copy of CATH domain 1.10.20.10 (Histone, subunit A) in Histone H3.3. Showing 1 copy in chain A.
The deposited structure of PDB entry 5kdm contains 1 copy of CATH domain 1.10.20.10 (Histone, subunit A) in Histone H4. Showing 1 copy in chain B.
1.20.58.2170
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homology: Methane Monooxygenase Hydroxylase; Chain G, domain 1
Occurring in:
  1. Death domain-associated protein 6
The deposited structure of PDB entry 5kdm contains 1 copy of CATH domain 1.20.58.2170 (Methane Monooxygenase Hydroxylase; Chain G, domain 1) in Death domain-associated protein 6. Showing 1 copy in chain C.

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