› 5k47

Electron Microscopy
4.2Å resolution

CryoEM structure of the human Polycystin-2/PKD2 TRP channel

Released:
DOI: 10.2210/pdb5k47/pdb
PDB entry 5k47 coloured by chain, front view.
PDB entry 5k47 coloured by chain, side view.
PDB entry 5k47 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2).
Grieben M, Pike AC, Shintre CA, Venturi E, El-Ajouz S, Tessitore A, Shrestha L, Mukhopadhyay S, Mahajan P, Chalk R, Burgess-Brown NA, Sitsapesan R, Huiskonen JT, Carpenter EP
Nat. Struct. Mol. Biol. (2016)
PMID: 27991905
Related structures: EMD-8200

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171761 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Polycystin-2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 547 amino acids
Theoretical weight: 63.99 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q13563 (Residues: 185-723; Coverage: 56%)
Gene names: PKD2, TRPP2
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 8 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.2Å
Relevant EMDB volumes: EMD-8200
Expression system: Spodoptera frugiperda

Quick links

Citations

29 review citations

Targeting nociceptive transient receptor potential channels to treat chronic pain: current state of the field.
Moran et al. (2018)
28 more

11 mentions without citation

Structural Pharmacology of TRP Channels.
Zhao et al. (2021)
10 more