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Structure of the unliganded form of the proprotein convertase furin.

Source organism: Homo sapiens
Biochemical function: serine-type peptidase activity
Biological process: proteolysis
Cellular component: not assigned

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EC 3.4.21.75: Furin

Reaction catalysed:
Release of mature proteins from their proproteins by cleavage of -Arg-Xaa-Yaa-Arg-|- bonds, where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors.
Alternative Name(s):
  • Dibasic processing enzyme
  • PACE
  • PC1
  • Paired basic amino acid cleaving enzyme
  • Paired basic amino acid converting enzyme
  • Paired basic amino acid residue cleaving enzyme
  • Prohormone convertase
  • Proprotein convertase
  • SPC3
  • Serine proteinase PACE

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF01483
Domain description: Proprotein convertase P-domain
Occurring in:
  1. Furin
The deposited structure of PDB entry 5jxg contains 1 copy of Pfam domain PF01483 (Proprotein convertase P-domain) in Furin. Showing 1 copy in chain A.

PF00082
Domain description: Subtilase family
Occurring in:
  1. Furin
The deposited structure of PDB entry 5jxg contains 1 copy of Pfam domain PF00082 (Subtilase family) in Furin. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR015500
Domain description: Peptidase S8, subtilisin-related
Occurring in:
  1. Furin
IPR002884
Domain description: P domain
Occurring in:
  1. Furin
IPR036852
Domain description: Peptidase S8/S53 domain superfamily
Occurring in:
  1. Furin
IPR008979
Domain description: Galactose-binding-like domain superfamily
Occurring in:
  1. Furin
IPR023828
Domain description: Peptidase S8, subtilisin, Ser-active site
Occurring in:
  1. Furin
IPR022398
Domain description: Peptidase S8, subtilisin, His-active site
Occurring in:
  1. Furin
IPR023827
Domain description: Peptidase S8, subtilisin, Asp-active site
Occurring in:
  1. Furin
IPR000209
Domain description: Peptidase S8/S53 domain
Occurring in:
  1. Furin
IPR034182
Domain description: Kexin/furin catalytic domain
Occurring in:
  1. Furin

Structure domains

CATH CATH domains
2.60.120.260
Class: Mainly Beta
Architecture: Sandwich
Topology: Jelly Rolls
Homology: Galactose-binding domain-like
Occurring in:
  1. Furin
The deposited structure of PDB entry 5jxg contains 1 copy of CATH domain 2.60.120.260 (Jelly Rolls) in Furin. Showing 1 copy in chain A.
3.40.50.200
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Peptidase S8/S53 domain
Occurring in:
  1. Furin
The deposited structure of PDB entry 5jxg contains 1 copy of CATH domain 3.40.50.200 (Rossmann fold) in Furin. Showing 1 copy in chain A.

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