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Crystal structure of complement C4b re-refined using iMDFF

Source organism: Homo sapiens
Biochemical function: endopeptidase inhibitor activity
Biological process: not assigned
Cellular component: extracellular region

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GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF01759
Domain description: UNC-6/NTR/C345C module
Occurring in:
  1. Complement C4 gamma chain
The deposited structure of PDB entry 5jtw contains 2 copies of Pfam domain PF01759 (UNC-6/NTR/C345C module) in Complement C4 gamma chain. Showing 1 copy in chain C.

PF07677
Domain description: A-macroglobulin receptor binding domain
Occurring in:
  1. Complement C4 gamma chain
The deposited structure of PDB entry 5jtw contains 2 copies of Pfam domain PF07677 (A-macroglobulin receptor binding domain) in Complement C4 gamma chain. Showing 1 copy in chain C.

PF07678
Domain description: A-macroglobulin TED domain
Occurring in:
  1. C4b-A
The deposited structure of PDB entry 5jtw contains 2 copies of Pfam domain PF07678 (A-macroglobulin TED domain) in C4b-A. Showing 1 copy in chain B.

PF00207
Domain description: Alpha-2-macroglobulin family
Occurring in:
  1. C4b-A
The deposited structure of PDB entry 5jtw contains 2 copies of Pfam domain PF00207 (Alpha-2-macroglobulin family) in C4b-A. Showing 1 copy in chain B.

PF07703
Domain description: Alpha-2-macroglobulin bait region domain
Occurring in:
  1. Complement C4 beta chain
The deposited structure of PDB entry 5jtw contains 2 copies of Pfam domain PF07703 (Alpha-2-macroglobulin bait region domain) in Complement C4 beta chain. Showing 1 copy in chain A.

PF17789
Domain description: Macroglobulin domain MG4
Occurring in:
  1. Complement C4 beta chain
The deposited structure of PDB entry 5jtw contains 2 copies of Pfam domain PF17789 (Macroglobulin domain MG4) in Complement C4 beta chain. Showing 1 copy in chain A.

PF17791
Domain description: Macroglobulin domain MG3
Occurring in:
  1. Complement C4 beta chain
The deposited structure of PDB entry 5jtw contains 2 copies of Pfam domain PF17791 (Macroglobulin domain MG3) in Complement C4 beta chain. Showing 1 copy in chain A.

PF01835
Domain description: MG2 domain
Occurring in:
  1. Complement C4 beta chain
The deposited structure of PDB entry 5jtw contains 2 copies of Pfam domain PF01835 (MG2 domain) in Complement C4 beta chain. Showing 1 copy in chain A.

PF21145
Domain description: Complement C4, MG1 domain
Occurring in:
  1. Complement C4 beta chain
The deposited structure of PDB entry 5jtw contains 2 copies of Pfam domain PF21145 (Complement C4, MG1 domain) in Complement C4 beta chain. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR018933
Domain description: Netrin module, non-TIMP type
Occurring in:
  1. Complement C4 gamma chain
IPR008993
Domain description: Tissue inhibitor of metalloproteinases-like, OB-fold
Occurring in:
  1. Complement C4 gamma chain
IPR036595
Domain description: Alpha-macroglobulin, receptor-binding domain superfamily
Occurring in:
  1. Complement C4 gamma chain
IPR001599
Domain description: Alpha-2-macroglobulin
Occurring in:
  1. C4b-A
IPR011625
Domain description: Alpha-2-macroglobulin, bait region domain
Occurring in:
  1. Complement C4 beta chain
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. Complement C4 beta chain
  2. C4b-A
IPR001134
Domain description: Netrin domain
Occurring in:
  1. Complement C4 gamma chain
IPR009048
Domain description: Alpha-macroglobulin, receptor-binding
Occurring in:
  1. Complement C4 gamma chain
IPR019742
Domain description: Alpha-2-macroglobulin, conserved site
Occurring in:
  1. C4b-A
IPR047565
Domain description: Alpha-macroglobulin-like, thiol-ester bond-forming region
Occurring in:
  1. C4b-A
IPR008930
Domain description: Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
Occurring in:
  1. C4b-A
IPR011626
Domain description: Alpha-macroglobulin-like, TED domain
Occurring in:
  1. C4b-A
IPR040839
Domain description: Macroglobulin domain MG4
Occurring in:
  1. Complement C4 beta chain
IPR041555
Domain description: Macroglobulin domain MG3
Occurring in:
  1. Complement C4 beta chain
IPR002890
Domain description: Macroglobulin domain
Occurring in:
  1. Complement C4 beta chain

Structure domains

CATH CATH domains
2.60.40.1930
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulin-like
Occurring in:
  1. Complement C4 beta chain
The deposited structure of PDB entry 5jtw contains 6 copies of CATH domain 2.60.40.1930 (Immunoglobulin-like) in Complement C4 beta chain. Showing 3 copies in chain A.
2.60.120.1540
Class: Mainly Beta
Architecture: Sandwich
Topology: Jelly Rolls
Homology: Jelly Rolls
Occurring in:
  1. C4b-A
The deposited structure of PDB entry 5jtw contains 2 copies of CATH domain 2.60.120.1540 (Jelly Rolls) in C4b-A. Showing 1 copy in chain B.
2.60.40.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulins
Occurring in:
  1. Complement C4 beta chain
  2. C4b-A
The deposited structure of PDB entry 5jtw contains 2 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in Complement C4 beta chain. Showing 1 copy in chain A.
The deposited structure of PDB entry 5jtw contains 2 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in C4b-A. Showing 1 copy in chain B.
1.50.10.20
Class: Mainly Alpha
Architecture: Alpha/alpha barrel
Topology: Glycosyltransferase
Homology: Glycosyltransferase
Occurring in:
  1. C4b-A
The deposited structure of PDB entry 5jtw contains 2 copies of CATH domain 1.50.10.20 (Glycosyltransferase) in C4b-A. Showing 1 copy in chain B.
2.20.130.20
Class: Mainly Beta
Architecture: Single Sheet
Topology: S-adenosyl-L-methionine-dependent methyltransferases
Homology: S-adenosyl-L-methionine-dependent methyltransferases
Occurring in:
  1. C4b-A
The deposited structure of PDB entry 5jtw contains 2 copies of CATH domain 2.20.130.20 (S-adenosyl-L-methionine-dependent methyltransferases) in C4b-A. Showing 1 copy in chain B.
6.20.50.160
Class: Special
Architecture: Other non-globular
Topology: N-terminal domain of TfIIb
Homology: N-terminal domain of TfIIb
Occurring in:
  1. Complement C4 beta chain
The deposited structure of PDB entry 5jtw contains 2 copies of CATH domain 6.20.50.160 (N-terminal domain of TfIIb) in Complement C4 beta chain. Showing 1 copy in chain A.
2.60.40.1940
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulin-like
Occurring in:
  1. Complement C4 beta chain
The deposited structure of PDB entry 5jtw contains 2 copies of CATH domain 2.60.40.1940 (Immunoglobulin-like) in Complement C4 beta chain. Showing 1 copy in chain A.

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