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Structure of human complement C4 rebuilt using iMDFF

X-ray diffraction
3.6Å resolution
PDB entry 5jpn coloured by chain, front view.
PDB entry 5jpn coloured by chain, side view.
PDB entry 5jpn coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: C4d-A
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Multimeric state: hetero trimer
Accessible surface area: 76278.79 Å2
Buried surface area: 21114.12 Å2
Dissociation area: 4,368.99 Å2
Dissociation energy (ΔGdiss): 61.63 kcal/mol
Dissociation entropy (TΔSdiss): 16.26 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-142895

Macromolecules

Complement C4 beta chain
Chain: A
Length: 656 amino acids
Theoretical weight: 71.76 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P0C0L4 (Residues: 20-675; Coverage: 38%)
Gene names: C4A, CO4, CPAMD2
Pfam:
InterPro:
CATH:
Complement C4 beta chain in PDB entry 5jpn, assembly 1, front view.
Complement C4 beta chain in PDB entry 5jpn, assembly 1, side view.
Complement C4 beta chain in PDB entry 5jpn, assembly 1, top view.
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Complement C4-A alpha chain
Chain: B
Length: 767 amino acids
Theoretical weight: 84.27 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P0C0L4 (Residues: 680-1446; Coverage: 45%)
Gene names: C4A, CO4, CPAMD2
Pfam:
InterPro:
CATH:
Complement C4-A alpha chain in PDB entry 5jpn, assembly 1, front view.
Complement C4-A alpha chain in PDB entry 5jpn, assembly 1, side view.
Complement C4-A alpha chain in PDB entry 5jpn, assembly 1, top view.
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Complement C4 gamma chain
Chain: C
Length: 290 amino acids
Theoretical weight: 32.99 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P0C0L4 (Residues: 1455-1744; Coverage: 17%)
Gene names: C4A, CO4, CPAMD2
Pfam:
InterPro:
CATH:
Complement C4 gamma chain in PDB entry 5jpn, assembly 1, front view.
Complement C4 gamma chain in PDB entry 5jpn, assembly 1, side view.
Complement C4 gamma chain in PDB entry 5jpn, assembly 1, top view.
Molecule details ›

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